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Environmental Science and Pollution Research

, Volume 26, Issue 18, pp 18886–18892 | Cite as

Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats

  • Dara Dastan
  • Sedigheh Karimi
  • Amir Larki-Harchegani
  • Amir Nili-AhmadabadiEmail author
Short Research and Discussion Article
  • 35 Downloads

Abstract

Cadmium (Cd), as a toxic metal, can accumulate in kidneys and induce renal failure. This study was undertaken to evaluate the protective effects of Allium hirtifolium Boiss bulbs against Cd-induced renal failure in rats. Thirty-six rats were divided into 6 groups: group 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and AhB extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which treated AhB extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, renal function and oxidative stress markers were determined by using colorimetric methods. Our findings showed that Cd caused a significant increase in creatinine (Cr; p<0.05), uric acid (p<0.01), BUN (p<0.05), serum levels, lipid peroxidation (LPO; p<0.01), and nitric oxide (NO; p<0.01); the depletion of the total antioxidant capacity (TAC; p<0.01) and total thiol molecules (TTM; p<0.001); and structural alterations in the renal tissue. Following AhB extract administration, a remarkable improvement was observed in the functional and oxidative stress markers of renal tissue.

This study suggests that AhB may prevent progression of Cd-induced renal failure via improvement of oxidative/antioxidant balance in renal tissue.

Keywords

Cadmium Renal failure Allium hirtifolium Boiss Oxidative stress 

Notes

Acknowledgements

Financial support for this work was provided by vice-chancellor for research and technology, Hamadan University of Medical Sciences, Hamadan, Iran (Grant No. 9412257444).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Dara Dastan
    • 1
    • 2
  • Sedigheh Karimi
    • 1
    • 3
  • Amir Larki-Harchegani
    • 1
    • 3
  • Amir Nili-Ahmadabadi
    • 1
    • 3
    Email author
  1. 1.Medicinal Plants and Natural Products Research CenterHamadan University of Medical SciencesHamadanIran
  2. 2.Department of Pharmacognosy and Pharmaceutical Biotechnology, School of PharmacyHamadan University of Medical SciencesHamadanIran
  3. 3.Department of Pharmacology and Toxicology, School of PharmacyHamadan University of Medical SciencesHamadanIran

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