Environmental Science and Pollution Research

, Volume 26, Issue 9, pp 9365–9370 | Cite as

Effect of bifenthrin on oxidative stress parameters in the liver, kidneys, and lungs of rats

  • Muneer Ahmad Dar
  • Adil Mehraj KhanEmail author
  • Rajinder Raina
  • Pawan Kumar Verma
  • Nasir Manzoor Wani
Research Article


Oxidative stress inducing potential of bifenthrin was evaluated in the liver, kidney, and lung of rats following its repeated oral administration for 20 and 30 days. Bifenthrin-treated rats showed a significant lipid peroxidation in all three tissues. By 20th day of treatment, there was a significant decrease in superoxide dismutase activity of the liver, catalase and glutathione peroxidase activity of the liver and lung, and glutathione S-transferase activity of the kidney and lung. By 30th day of exposure, the activities of these enzymes were significantly decreased in all three tissues. The highest oxidative stress, indicated by lipid peroxidation and alteration in antioxidant enzymes, is produced in the liver followed by the kidney and lung. In conclusion, bifenthrin has a potential to induce severe oxidative stress in the liver, kidney, and lung. The extent of oxidative stress is increased with the duration of exposure.


Bifenthrin Oxidative stress Liver Kidney Lung 


Compliance with ethical standards

The experimental design was approved by the University Animal Ethical Committee with registration number, 862/ac/04/CPCSEA.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Muneer Ahmad Dar
    • 1
  • Adil Mehraj Khan
    • 1
    • 2
    Email author
  • Rajinder Raina
    • 1
  • Pawan Kumar Verma
    • 1
  • Nasir Manzoor Wani
    • 1
  1. 1.Department of Veterinary Pharmacology and ToxicologySher-e-Kashmir University of Agricultural Sciences and TechnologyJammuIndia
  2. 2.Division of Veterinary Pharmacology and ToxicologySher-e-Kashmir University of Agricultural Sciences and TechnologyKashmirIndia

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