Environmental Science and Pollution Research

, Volume 26, Issue 6, pp 5971–5982 | Cite as

Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats

  • Samuel Gbadebo OlukoleEmail author
  • Damilare Olaniyi Lanipekun
  • Eunice Olufunke Ola-Davies
  • Bankole Olusiji Oke
Research Article


This study investigated the role of melatonin (MLT) on adrenal gland toxicity induced by bisphenol A (BPA). Adult male rats were divided into four groups of seven animals each: Group I (control) received oral 0.2 ml canola oil; group II received intra-peritoneal 10 mg/kg BW/day MLT; and group III received oral BPA (10 mg/kg BW/day). Group IV rats were treated with same dose of BPA as group III with a concomitant intra-peritoneal 10 mg/kg BW/day MLT. All treatments lasted for 14 days. BPA significantly increased (P < 0.05) adrenal index, circulating levels of corticosterone and adrenocorticotropic hormone (ACTH) in the rats. BPA caused marked vascular congestion, hyperplasia, cellular distortion, increased lipid peroxidation, decreased antioxidant enzymes, and decreased expression of αSmooth muscle actin as well as vimentin proteins. The concomitant treatment with MLT ameliorated these BPA-induced alterations. It is likely that melatonin attenuates BPA-induced alterations of the adrenal gland of rats through the antioxidant defense mechanism.


Bisphenol A toxicity Melatonin attenuation Adrenal gland Corticosterone Adrenocorticotropic hormone 



The authors hereby acknowledge the technical assistance received from the Pathology Section, Department of Para-clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa. Dr. S.G. Olukole was a Post-Doctoral Fellow, Department of Anatomy and Physiology, Faculty of Veterinary Science, University of Pretoria, South Africa. Dr. Tayo Omobowale of the Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria provided the melatonin used in the study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Veterinary AnatomyUniversity of IbadanIbadanNigeria
  2. 2.Department of Veterinary Physiology and BiochemistryUniversity of IbadanIbadanNigeria

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