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Larvicidal and pupicidal activities of eco-friendly phenolic lipid products from Anacardium occidentale nutshell against arbovirus vectors

  • George Harrison Ferreira de Carvalho
  • Milene Aparecida de Andrade
  • Carla Nunes de Araújo
  • Maria Lucília Santos
  • Natália Alves de Castro
  • Sébastien Charneau
  • Rose Monnerat
  • Jaime Martins de SantanaEmail author
  • Izabela Marques Dourado BastosEmail author
Research Article
  • 26 Downloads

Abstract

Aedes aegypti and Culex quinquefasciatus are vectors of diseases that constitute public health problems. The discovery of products capable of inhibiting their development which are less harmful to the environment would have a huge impact on vector control. Here, natural cashew nut shell liquid (CNSL), technical CNSL, anacardic acid, cardanol, and cardol were isolated from Anacardium occidentale and evaluated for larvicidal and pupicidal activity against Ae. aegypti and Cx. quinquefasciatus under laboratory and field conditions. The activities of phenol, resorcinol, salicylic acid, and pentadecane, commercial chemicals similar in structure to nut shell derivatives, were also evaluated. All of the fractions extracted from A. occidentale oil exerted larvicidal effects against both mosquito species (LC50 5.4–22.6 mg/L), and two of the aforementioned were effective against pupae (LC50 90.8–109.7 mg/L). Of all the fractions tested, cardol demonstrated the strongest larvicidal and pupicidal effects and presented the most prolonged residual activity against the larvae and pupae of Ae. aegypti and Cx. quinquefasciatus under field conditions. This study suggests that A. occidentale nut shell derivatives are sustainable and promising candidates for the development of novel insecticides to overcome the problem of harmful chemical insecticides.

Keywords

Aedes aegypti Culex quinquefasciatus Insecticidal activity Cashew nut shell liquid (CNSL) Field experiment Cardol Cardanol Anacardic acid 

Notes

Acknowledgements

We would like to thank EMBRAPA Genetic Resources and Biotechnology for providing the third instar larvae and pupae of Ae. aegypti and Cx. quinquefasciatus.

Funding

This work was supported by grants and fellowships awarded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, grant 923/18 CAPES-COFECUB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, INCT-MCTI/CNPq/CAPES/FAPs 16/2014), Fundação de Amparo à Pesquisa do Distrito Federal (FAP-DF, grants 0913.000.417/2016 and 0193.001803/2017), and the Empresa Brasileira de Pesquisa Agropecuária (Embrapa).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • George Harrison Ferreira de Carvalho
    • 1
  • Milene Aparecida de Andrade
    • 1
  • Carla Nunes de Araújo
    • 1
  • Maria Lucília Santos
    • 2
  • Natália Alves de Castro
    • 1
  • Sébastien Charneau
    • 3
  • Rose Monnerat
    • 4
  • Jaime Martins de Santana
    • 1
    Email author
  • Izabela Marques Dourado Bastos
    • 1
    Email author return OK on get
  1. 1.Pathogen-Host Interface Laboratory, Department of Cell BiologyUniversity of BrasiliaBrasiliaBrazil
  2. 2.Institute of ChemistryUniversity of BrasiliaBrasiliaBrazil
  3. 3.Laboratory of Protein Chemistry and Biochemistry, Department of Cell BiologyUniversity of BrasiliaBrasiliaBrazil
  4. 4.Embrapa Genetic Resources and BiotechnologyBrasiliaBrazil

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