Investigation of antibiotics in sea cucumbers: occurrence, pollution characteristics, and human risk assessment
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Occurrence and distribution of 24 antibiotics from 7 categories were screened in sea cucumbers (Echinodermata: Holothuroidea) collected from different coastal regions of China. The samples were simultaneously extracted and purified using accelerated solvent extraction with in-cell clean-up and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. A total of ten antibiotics were detected in the sea cucumbers with concentrations ranging from not detected to 32.8 μg/kg (dry weight). Sulfonamides are predominant antibiotics with a mean concentration of 11.5 μg/kg (dry weight), followed by macrolides (11.3 μg/kg, dry weight) and fluoroquinolones (11.2 μg/kg, dry weight). High concentrations of the antibiotics were found in the samples from the South China Sea, implying that the antibiotic pollution in sea cucumbers was geographical region-dependent, which was further confirmed by principal component analysis. It was also found that the antibiotic levels are slightly higher in instant sea cucumbers than in the dried ones. Hazard quotient calculation suggested no obvious human health risks associated with the consumption of sea cucumbers regarding antibiotics.
KeywordsSulfonamides Macrolides Fluoroquinolones Sea cucumber Occurrence Risk assessment
This study was supported by the National Natural Science Foundation of China (No. 21661142001).
- Álvarez-Muñoz D, Rodríguez-Mozaz S, Maulvault AL, Tediosi A, Fernández-Tejedor M, Van den Heuvel F, Kotterman M, Marques A, Barceló D (2015) Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe. Environ Res 143:56–64CrossRefGoogle Scholar
- Farjami B, Nematollahi M, Moradi Y, Nazemi M (2014) Derivation of extracts from Persian Gulf sea cucumber (Holothuria leucospilota) and assessment of its antifungal effect. Iran J Fish Sci 13:785–795Google Scholar
- Li C, Li H, Guo S, Li X, Zhu X (2015) Evaluation of processing methods on the nutritional quality of sea cucumber (Apostichopus japonicus Selenka). Journal of Aquatic Food Product Technology 4:406–417Google Scholar
- Magnusson B & Örnemark U (2014) Eurachem Guide: the fitness for purpose of analytical methods—a laboratory guide to method validation and related topics. ISBN 978-91-87461-59-0. Available from www.eurachem.org
- U.S. Environmental Protection Agency (2000) Guidance for assessing chemical contaminant data for use in fish advisories-risk assessment and fish consumption limits, 3rd edn. Office of Water, Washington, DCGoogle Scholar
- Wei X, Chen J, Xie Q, Zhang S, Li Y, Zhang Y, Xie H (2015) Photochemical behavior of antibiotics impacted by complexation effects of concomitant metals: a case for ciprofloxacin and Cu(II). Environmental Science: Processes & Impacts 17:1220–1227Google Scholar
- World Health Organization (WHO) (2014). Antimicrobial resistance: global report on surveillance. Geneva, Switzerland. < http://www.who.int/iris/handle/10665/259744 > ISSN 9789241513449
- Zhang X, Chen S, Xu H, Zhang S, Yan Z, Wang J (2016) Identification and occurrence of endogenous semicarbazide in prawns and crabs from Zhejiang Province, China. Food Additives & Contaminants: Part A 33:252–258Google Scholar
- Zhao JL, Liu YS, Liu WR, Jiang YX, Su HC, Zhang QQ, Chen XW, Yang YY, Chen J, Liu SS, Pan CG, Huang GY, Ying GG (2015) Tissue-specific bioaccumulation of human and veterinary antibiotics in bile, plasma, liver and muscle tissues of wild fish from a highly urbanized region. Environ Pollut 198:15–24CrossRefGoogle Scholar