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Environmental Science and Pollution Research

, Volume 25, Issue 30, pp 30151–30159 | Cite as

Acute effects of air pollution on type II diabetes mellitus hospitalization in Shijiazhuang, China

  • Jie Song
  • Yue Liu
  • Liheng Zheng
  • Lihui Gui
  • Xiangmei Zhao
  • Dongqun Xu
  • Weidong Wu
Research Article

Abstract

Air pollution has been considered as an important contributor to diabetes development. However, the evidence is fewer in developing countries where air pollution concentrations were much higher. In this study, we conduct a time-series study to investigate the acute adverse effect of six air pollutants on type II diabetes mellitus (T2DM) hospitalization in Shijiazhuang, China. An over-dispersed passion generalized addictive model adjusted for weather conditions, day of the week, and long-term and seasonal trends was used. Finally, a 10-μg/m3 increase of fine particulate matter (PM2.5), inhalable particulate matter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and carbon monoxide (CO) corresponded to 0.53% (95% confidence interval = 0.22–0.83), 0.32% (95% CI = 0.10–0.55), 0.55% (95% CI = 0.04–1.07), 1.27% (95% CI = 0.33–2.22), and 0.04% (95% CI = 0.02–0.06) increment of T2DM hospitalization, respectively. The effects of PM2.5, PM10, and CO were robust when adjusted for co-pollutants. The associations appeared to be a little stronger in the cool season than in the warm season. And stronger associations were found in male and elderly (≥ 65 years) than in female and younger people (35–65 years). Our results contribute to the limited data in the scientific literature on acute effects of air pollution on type II diabetes mellitus in developing countries. Main findings: This is the first adverse effect evidence of air pollution on T2DM in Shijiazhuang, a severely polluted city in China. Males were more vulnerable than females in severe pollution.

Keywords

Air pollution Type II diabetes mellitus Hospitalization Time-series study 

Notes

Funding

The study was supported by the National Natural Science Foundation of China (21677136), the Ph.D. Research Project of Xinxiang Medical University (XYBSKYZZ201804), Key Scientific Research Projects in Universities of Henan Province (19B330004), and Peak Subject Project of Public Health in Xinxiang Medical University.

Compliance with Ethical Standards

Conflict of Interest

The authors declare they have no actual or potential competing financial interests.

Ethics Approval

This study does not involve experimental animals or individual information of human subjects.

References

  1. Cao J, Li W, Tan J, Song W, Xu X, Jiang C, Chen G, Chen R, Ma W, Chen B, Kan H (2009) Association of ambient air pollution with hospital outpatient and emergency room visits in Shanghai, China. Sci Total Environ 407:5531–5536CrossRefGoogle Scholar
  2. Chen R, Zhang Y, Yang C, Zhao Z, Xu X, Kan H (2013) Acute effect of ambient air pollution on stroke mortality in the China air pollution and health effects study. Stroke 44:954–960CrossRefGoogle Scholar
  3. Dales RE, Cakmak S, Vidal CB, Rubio MA (2012) Air pollution and hospitalization for acute complications of diabetes in Chile. Environ Int 46:1–5CrossRefGoogle Scholar
  4. Dzhambov AM, Dimitrova DD (2016) Exposures to road traffic, noise, and air pollution as risk factors for type 2 diabetes: a feasibility study in Bulgaria. Noise Health 18:133–142CrossRefGoogle Scholar
  5. Eze IC, Hemkens LG, Bucher HC, Hoffmann B, Schindler C, Kunzli N, Schikowski T, Probst-Hensch NM (2015) Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis. Environ Health Perspect 123:381–389CrossRefGoogle Scholar
  6. Kawada T (2015) Air pollution and diabetes mellitus. Diabetes Res Clin Pract 108:e7CrossRefGoogle Scholar
  7. Lao XQ, Zhang Z, Lau AK, Chan TC, Chuang YC, Chan J, Lin C, Guo C, Jiang WK, Tam T, Hoek G, Kan H, Yeoh EK, Chang LY (2017) Exposure to ambient fine particulate matter and semen quality in Taiwan. Occup Environ MedGoogle Scholar
  8. Lee H, Honda Y, Hashizume M, Guo YL, Wu CF, Kan H, Jung K, Lim YH, Yi S, Kim H (2015) Short-term exposure to fine and coarse particles and mortality: a multicity time-series study in East Asia. Environ Pollut 207:43–51CrossRefGoogle Scholar
  9. Liu C, Chen R, Zhao Y, Ma Z, Bi J, Liu Y, Meng X, Wang Y, Chen X, Li W, Kan H (2017) Associations between ambient fine particulate air pollution and hypertension: a nationwide cross-sectional study in China. Sci Total Environ 584-585:869–874CrossRefGoogle Scholar
  10. Lockwood AH (2002) Diabetes and air pollution. Diabetes Care 25:1487–1488CrossRefGoogle Scholar
  11. McLaughlin T, Lamendola C, Coghlan N, Liu TC, Lerner K, Sherman A, Cushman SW (2014) Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat. Obesity (Silver Spring) 22:673–680CrossRefGoogle Scholar
  12. Meng X, Ma Y, Chen R, Zhou Z, Chen B, Kan H (2013) Size-fractionated particle number concentrations and daily mortality in a Chinese city. Environ Health Perspect 121:1174–1178CrossRefGoogle Scholar
  13. Nicole W (2015) Air pollution and diabetes risk: assessing the evidence to date. Environ Health Perspect 123:A134Google Scholar
  14. Niu Y, Chen R, Liu C, Ran P, Chen A, Chen X, Kan H (2016) The association between ambient temperature and out-of-hospital cardiac arrest in Guangzhou, China. Sci Total Environ 572:114–118CrossRefGoogle Scholar
  15. O'Donovan G, Chudasama Y, Grocock S, Leigh R, Dalton AM, Gray LJ, Yates T, Edwardson C, Hill S, Henson J, Webb D, Khunti K, Davies MJ, Jones AP, Bodicoat DH, Wells A (2017) The association between air pollution and type 2 diabetes in a large cross-sectional study in Leicester: the CHAMPIONS Study. Environ Int 104:41–47CrossRefGoogle Scholar
  16. Paoletti E, Materassi A, Fasano G, Hoshika Y, Carriero G, Silaghi D, Badea O (2017) A new-generation 3D ozone FACE (Free Air Controlled Exposure). Sci Total Environ 575:1407–1414CrossRefGoogle Scholar
  17. Park SK (2017) Ambient air pollution and type 2 diabetes: do the metabolic effects of air pollution start early in life? Diabetes 66:1755–1757CrossRefGoogle Scholar
  18. Park SK, Wang W (2014) Ambient air pollution and type 2 diabetes: a systematic review of epidemiologic research. Curr Environ Health Rep 1:275–286CrossRefGoogle Scholar
  19. Patel P, Abate N (2013) Body fat distribution and insulin resistance. Nutrients 5:2019–2027CrossRefGoogle Scholar
  20. Pettit AP, Kipen H, Laumbach R, Ohman-Strickland P, Kelly-McNeill K, Cepeda C, Fan ZH, Amorosa L, Lubitz S, Schneider S, Gow A (2015) Disrupted nitric oxide metabolism from type II diabetes and acute exposure to particulate air pollution. PLoS One 10:e0144250CrossRefGoogle Scholar
  21. Poppendieck DG, Rim D, Persily AK (2014) Ultrafine particle removal and ozone generation by in-duct electrostatic precipitators. Environ Sci Technol 48:2067–2074CrossRefGoogle Scholar
  22. Rajagopalan S, Brook RD (2012) Air pollution and type 2 diabetes: mechanistic insights. Diabetes 61:3037–3045CrossRefGoogle Scholar
  23. Rao X, Montresor-Lopez J, Puett R, Rajagopalan S, Brook RD (2015) Ambient air pollution: an emerging risk factor for diabetes mellitus. Curr Diab Rep 15:603CrossRefGoogle Scholar
  24. Renzi M, Cerza F, Gariazzo C, Agabiti N, Cascini S, Di Domenicantonio R, Davoli M, Forastiere F, Cesaroni G (2017) Air pollution and occurrence of type 2 diabetes in a large cohort study. Environ Int 112:68–76CrossRefGoogle Scholar
  25. Samet JM, Zeger SL, Dominici F, Curriero F, Coursac I, Dockery DW, Schwartz J, Zanobetti A (2000) The National Morbidity, Mortality, and Air Pollution Study. Part II: morbidity and mortality from air pollution in the United States. Res Rep Health Eff Inst 94:5–70 discussion 71-79Google Scholar
  26. Sohn D, Oh H (2017) Gender-dependent differences in the relationship between diabetes mellitus and ambient air pollution among adults in South Korean cities. Iran J Public Health 46:293–300Google Scholar
  27. Stafoggia M, Forastiere F, Faustini A, Biggeri A, Bisanti L, Cadum E, Cernigliaro A, Mallone S, Pandolfi P, Serinelli M, Tessari R, Vigotti MA, Perucci CA, EpiAir G (2010) Susceptibility factors to ozone-related mortality: a population-based case-crossover analysis. Am J Respir Crit Care Med 182:376–384CrossRefGoogle Scholar
  28. Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, Cai Y, Ostrowski MC, Lu B, Parthasarathy S, Brook RD, Moffatt-Bruce SD, Chen LC, Rajagopalan S (2009) Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538–546CrossRefGoogle Scholar
  29. Thiering E, Heinrich J (2015) Epidemiology of air pollution and diabetes. Trends Endocrinol Metab 26:384–394CrossRefGoogle Scholar
  30. Tong L, Li K, Zhou Q (2015) The association between air pollutants and morbidity for diabetes and liver diseases modified by sexes, ages, and seasons in Tianjin. China Environ Sci Pollut Res Int 22:1215–1219CrossRefGoogle Scholar
  31. Wang LT, W.Z., Yang J, Zhang Y, Zhang FF, Su J, Meng CC, Zhang Q, 2014. The 2013 severe haze over southern Hebei, China: model evaluation, source apportionment, and policy implications, Atmos Chem Phys 14, 3151–3173CrossRefGoogle Scholar
  32. Xu X, Yavar Z, Verdin M, Ying Z, Mihai G, Kampfrath T, Wang A, Zhong M, Lippmann M, Chen LC, Rajagopalan S, Sun Q (2010) Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol 30:2518–2527CrossRefGoogle Scholar
  33. Yang C, Chen A, Chen R, Qi Y, Ye J, Li S, Li W, Liang Z, Liang Q, Guo D, Kan H, Chen X (2014) Acute effect of ambient air pollution on heart failure in Guangzhou, China. Int J Cardiol 177:436–441CrossRefGoogle Scholar
  34. Yang S, Ma YL, Duan FK, He KB, Wang LT, Wei Z, Zhu LD, Ma T, Li H, Ye SQ (2018) Characteristics and formation of typical winter haze in Handan, one of the most polluted cities in China. Sci Total Environ 613-614:1367–1375CrossRefGoogle Scholar
  35. Zanobetti A, Schwartz J (2011) Ozone and survival in four cohorts with potentially predisposing diseases. Am J Respir Crit Care Med 184:836–841CrossRefGoogle Scholar
  36. Zhang Y, Li C, Feng R, Zhu Y, Wu K, Tan X, Ma L (2016) The short-term effect of ambient temperature on mortality in Wuhan, China: a time-series study using a distributed lag non-linear model. Int J Environ Res Public Health 13CrossRefGoogle Scholar
  37. Zhao A, Chen R, Kuang X, Kan H (2014) Ambient air pollution and daily outpatient visits for cardiac arrhythmia in Shanghai, China. J Epidemiol 24:321–326CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jie Song
    • 1
    • 2
  • Yue Liu
    • 3
  • Liheng Zheng
    • 4
  • Lihui Gui
    • 1
  • Xiangmei Zhao
    • 1
  • Dongqun Xu
    • 3
  • Weidong Wu
    • 1
    • 2
  1. 1.School of Public HealthXinxiang Medical UniversityXinxiangChina
  2. 2.Henan International Collaborative Laboratory for Health Effects and Intervention of Air PollutionXinxiangChina
  3. 3.National Institute of Environmental Health, Chinese Center for Disease Control and PreventionBeijingChina
  4. 4.Hebei Chest HospitalShijiazhuangChina

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