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Environmental Science and Pollution Research

, Volume 26, Issue 18, pp 17974–17985 | Cite as

Impact of PM10 and meteorological factors on the incidence of hand, foot, and mouth disease in female children in Ningbo, China: a spatiotemporal and time-series study

  • Ruixue Huang
  • Huacheng Ning
  • Tianfeng He
  • Guolin Bian
  • Jianan HuEmail author
  • Guozhang XuEmail author
Environmental Pollution and Energy Management

Abstract

Hand, foot, and mouth disease (HFMD) is a viral illness that is considered a critical public health challenge worldwide. Previous studies have demonstrated that meteorological parameters are significantly related to the incidence of HFMD in children; however, few studies have focused only on female children. This study quantified the associations of HFMD incidence with meteorological parameters and PM10 (particulate matter with an aerodynamic diameter of 10 μm) among female children. Data were collected on daily HFMD cases, meteorological variables, and PM10 levels in Ningbo, China, from January 2012 to December 2016. Data were assessed using a distributed lag nonlinear model (DLNM) with Poisson distribution. A total of 59,809 female children aged 0−15 years with HFMD were enrolled. The results showed that highest relative risk (RR) of HFMD for temperature was 3 °C and the lag effect was 3 days. The highest RR for PM10 was 80 mg/m3 and the lag effect was 5 days. Spatial analysis showed that female HFMD incidence was mainly concentrated in the suburban of Ningbo city indicating that female children in this area should be more paid attention on avoiding this disease outbreak. Our findings suggest that HFMD prevention strategies should focus more attention on local meteorological parameters.

Keywords

Hand, foot, and mouth disease Female children Spatiotemporal study Incidence 

Notes

Authors’ contributions

H RX, B GL, and H TF conceived and designed the experiments; H RX, B GL, and H TF performed the experiments; H TF and HC N analyzed the data; H RX, HC N, H JA, and X GZ drafted the paper. All authors contributed to the interpretation of the analysis, reviewing the manuscript.

Funding

This study was supported by the Graduate students’ independent exploration of innovative projects, Central South University (2018zzts849), Health and Medical Science and Technology Scheme of Zhejiang Province (2014KYA202), the Science and Technology Scheme of Ningbo (2014C50027), the Science and Technology Scheme of Health and Family Planning Commission of Hunan Province (BZ2016085), supported by and the Innovation Team of Science and Technology Bureau of Ningbo (2012B82018), the Social Development Research Program of Ningbo (2014C50025), Science and Technology Innovation, Science Popularization Guidance Project of Hunan Province (2016ZK3002).

Compliance with ethical standards

Ethics approval and consent to participate

This study has been approved by the Institutional Review Board of the Ningbo Center for Disease Control. Data analyses were de-identified (number 201601).

Consent for publication

Not applicable.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Occupational and Environmental Health, Xiangya School of Public HealthCentral South UniversityChangshaChina
  2. 2.Ningbo Municipal Center for Disease Control and PreventionNingboChina

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