Environmental Science and Pollution Research

, Volume 26, Issue 5, pp 4415–4425 | Cite as

Antituberculosis drug isoniazid degraded by electro-Fenton and photoelectro-Fenton processes using a boron-doped diamond anode and a carbon-PTFE air-diffusion cathode

  • Diego R. V. Guelfi
  • Fábio Gozzi
  • Ignasi SirésEmail author
  • Enric Brillas
  • Amílcar MachulekJr
  • Silvio César de OliveiraEmail author
Advanced Oxidation Technologies: State-of-the-Art in Ibero-American Countries


Solutions with 0.65 mM of the antituberculosis drug isoniazid (INH) in 0.050 M Na2SO4 at pH 3.0 were treated by electro-Fenton (EF) and UVA photoelectro-Fenton (PEF) processes using a cell with a BDD anode and a carbon-PTFE air-diffusion cathode. The influence of current density on degradation, mineralization rate, and current efficiency has been thoroughly evaluated in EF. The effect of the metallic catalyst (Fe2+ or Fe3+) and the formation of products like short-chain linear aliphatic carboxylic acids were assessed in PEF. Two consecutive pseudo-first-order kinetic regions were found using Fe2+ as catalyst. In the first region, at short time, the drug was rapidly oxidized by OH, whereas in the second region, at longer time, a resulting Fe(III)-INH complex was much more slowly removed by oxidants. INH disappeared completely at 300 min by EF, attaining 88 and 94% mineralization at 66.6 and 100 mA cm−2, respectively. Isonicotinamide and its hydroxylated derivative were identified as aromatic products of INH by GC-MS and oxalic, oxamic, and formic acids were quantified by ion-exclusion HPLC. The PEF treatment of a real wastewater polluted with the drug led to slower INH and TOC abatements because of the parallel destruction of its natural organic matter content.


Electro-Fenton Isoniazid Oxidation products Photoelectro-Fenton Real wastewater Water treatment 



The authors thank funding from the Brazilian funding agencies: Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT-MS), Pró-Reitoria de Pesquisa e Pós-Graduação da Universidade Federal de Mato Grosso do Sul (PROPP-UFMS), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ). The authors also thank financial support from project CTQ2016-78616-R (AEI/FEDER, EU).


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Diego R. V. Guelfi
    • 1
  • Fábio Gozzi
    • 1
  • Ignasi Sirés
    • 2
    Email author
  • Enric Brillas
    • 2
  • Amílcar MachulekJr
    • 1
  • Silvio César de Oliveira
    • 1
    Email author
  1. 1.Instituto de Química (INQUI)Universidade Federal de Mato Grosso do SulCampo GrandeBrazil
  2. 2.Laboratori d’Electroquímica dels Materials i del Medi Ambient, Departament de Química Física, Facultat de QuímicaUniversitat de BarcelonaBarcelonaSpain

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