Environmental Science and Pollution Research

, Volume 25, Issue 10, pp 9371–9379 | Cite as

Teratogenic effects induced by chitosan oligosaccharide in Wistar female rat Rattus norvegicus

  • Amal Abdel Aziz Eisa
  • Gamal El-Sayed Aboelghar
  • Ibrahim Mahmoud Ammar
  • Hala Gabr Metwally
  • Samah Saied Arafa
Research Article
  • 211 Downloads

Abstract

The aim of this research is to investigate the teratogenic effects of chitosan oligosaccharide in Wistar female rats (Rattus norvegicus). Chitosan LD50 value was calculated by probit analysis. High dose, 1/10 LD50 which equal to 150 mg/kg body weight, and low dose, 1/30 LD50 which equal to 50 mg/kg body weight, were administrated orally to Wistar female rats to examine the teratogenic effect during organogenesis period from 6th day to 15th day of gestation. Treated and control rats were sacrificed and their foetuses were examined for external, skeletal and visceral anomalies, number and length of foetuses and their weights. Obtained results showed toxicity and teratogenic effects of chitosan on treated rats and their progenies, i.e. high fetal mortality, offspring’s weight and length reduction, and high incidence of fetal external, skeletal and visceral abnormalities. This suggested that chitosan is a teratogenic compound, restricted to current results from orally treated Wistar rats.

Keywords

Wistar rat Rattus norvegicus Teratogenic Chitosan oligosaccharide 

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Amal Abdel Aziz Eisa
    • 1
  • Gamal El-Sayed Aboelghar
    • 1
  • Ibrahim Mahmoud Ammar
    • 1
  • Hala Gabr Metwally
    • 2
  • Samah Saied Arafa
    • 1
  1. 1.Pesticides Department, Faculty of AgricultureMenoufia UniversityShibin El KomEgypt
  2. 2.Clinical Pathology Department, Faculty of MedicineCairo UniversityGizaEgypt

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