Environmental Science and Pollution Research

, Volume 25, Issue 30, pp 29794–29807 | Cite as

Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals

  • Qassim Esmaeel
  • Maude Pupin
  • Philippe Jacques
  • Valérie LeclèreEmail author
Chemistry, Activity and Impact of Plant Biocontrol products


Bacteria belonging to the genus Burkholderia live in various ecological niches and present a significant role in the environments through the excretion of a wide variety of secondary metabolites including modular nonribosomal peptides (NRPs) and polyketides (PKs). These metabolites represent a widely distributed biomedically and biocontrol important class of natural products including antibiotics, siderophores, and anticancers as well as biopesticides that are considered as a novel source that can be used to defend ecological niche from competitors and to promote plant growth. The aim of this review is to present all NRPs produced or potentially produced by strains of Burkholderia, as NRPs represent a major source of active compounds implicated in biocontrol. The review is a compilation of results from a large screening we have performed on 48 complete sequenced genomes available in NCBI to identify NRPS gene clusters, and data found in the literature mainly because some interesting compounds are produced by strains not yet sequenced. In addition to NRPs, hybrids NRPs/PKs are also included. Specific features about biosynthetic gene clusters and structures of the modular enzymes responsible for the synthesis, the biological activities, and the potential uses in agriculture and pharmaceutical of NRPs and hybrids NRPs/PKs will also be discussed.


Burkholderia NRPS Hybrid NRPS/PKS Biocontrol Lipopeptides Siderophores 



This work was supported by the University of Lille 1, the INTERREG IVa program France-Wallonie-Vlaanderen (Phytobio project), the INTERREGVa program (SmartBioControle/BioScreen project), and the bioinformatics platform bilille.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Qassim Esmaeel
    • 1
    • 2
  • Maude Pupin
    • 3
    • 4
  • Philippe Jacques
    • 1
    • 5
  • Valérie Leclère
    • 1
    • 3
    • 4
    Email author
  1. 1.University Lille, INRA, ISA, University Artois, University Littoral Côte d’Opale, EA 7394-ICV- Institut Charles ViolletteLilleFrance
  2. 2.Laboratoire de Stress, Défenses et Reproduction des Plantes URVVC-EA 4707, UFR Sciences Exactes et NaturellesUniversity of Reims-Champagne-ArdenneReimsFrance
  3. 3.University Lille, CNRS, Centrale Lille, UMR 9189- CRIStAL- Centre de Recherche en Informatique Signal et Automatique de LilleLilleFrance
  4. 4.Inria-Lille Nord Europe, Bonsai teamVilleneuve d’Ascq CedexFrance
  5. 5.TERRA Research Centre, Microbial Processes and Interactions (MiPI)Gembloux Agro-Bio Tech University of LiegeGemblouxBelgium

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