10 km running race induces an elevation in the plasma myokine level of nonprofessional runners
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Acute and chronic physical exercise is believed to have beneficial effects on human health. Exercise is also able to modulate immune function. We hypothesed that exercise is able to induce many benefits for human health by modulating immune functions through the production and release of many myokines. Here, we investigated the effects of a running race on the level of plasmatic myokines.
Nine male volunteers took part in this study. Blood samples were obtained before, immediately after and 24 h after the race.
Participants completed the 10 km running race in 49.85 ± 7.04 min. The levels of IL-6 elevated after exercise (0.94 ± 0.4–2.82 ± 0.3 pg/ml). The IL-15 plasma level was also higher immediately after (0.88 ± 0.25–1.29 ± 0.36 pg/ml), and 24 h after (1.30 ± 1.01 pg/ml), the end of the exercise. Irisin increased only 24 h after exercise (632.60 ± 188.40–974.70 ± 232.30 pg/ml). FABP3 increased after exercise (829.60 ± 68.93–1306.00 ± 319.10 pg/ml). The plasma levels of BDNF (4719.00 ± 701.80–5557.00 ± 810.30 pg/ml) and Fractalkine increased after exercise (101.2 ± 34.96–134.90 ± 43.62 pg/ml). The level of FSTL (7265.00 ± 1553.00–9074.00 ± 1662.00 pg/ml) and Osteonectin (16.52 ± 3.54–15.71 ± 3.38 pg/ml) also increased after exercise, and then returned to baseline level 24 h after the end of the session.
Taken together, these results suggest that a 10 km running race induces elevation of important myokine plasma levels.
KeywordsExercise Myokines Running Skeletal muscle
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Santa Casa Hospital in Belo Horizonte, MG, Brazil (466/2012) n. 074/2007.) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Written informed consent was obtained from all individual participants included in the study.
- 1.McArdle WD, Katch FI, Katch VL (2011) Fisiologia do Exercício: energia, nutrição e desempenho humano. Editora Guanabara Koogan, Sétima ediçãoGoogle Scholar
- 5.Rabin BS Moyna MN, Kusnecov A, Zhou D, Shurin MR (1996) Neuroendocrine effects of immunity. Exerc Immune Funct 21–38Google Scholar
- 8.Nunes-Silva A, Matos JM, Freitas-Lima LC, Gomes EC, Nogueira-Machado JA, Vieira ELM et al (2018) Intense aerobic exercise modifies leucocytes number, lymphocyte subpopulation and cytokine levels in peripheral blood. Gazzetta Medica Italiana Archivio per le Scienze Mediche 177(3):79–87Google Scholar
- 13.Lammers G, Poelkens F, Duijnhoven NTL, Pardoel EM, Hoenderop JG, Thijssen DHJ et al (2012) Expression of genes involved in fatty acid transport and insulin signaling is altered by physical inactivity and exercise training in human skeletal muscle. Am J Physiol Endocrinol Metabol 303(10):E1245–E1251CrossRefGoogle Scholar
- 27.Fortunato AK, Pontes WM, De Souza DMS, Prazeres JSF, Marcucci-Barbosa LS, Santos JMM, Da Silva AN (2018) Strength Training Session induces important changes on physiological, immunological, and inflammatory biomarkers. J Immunol Res. https://doi.org/10.1155/2018/9675216 CrossRefPubMedPubMedCentralGoogle Scholar