The effect of aerobic exercise on various symptoms of depression: the mediating role of quality of life
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The aim of this study is to assess the effect of aerobic exercise on the three categories of somatic, affective and cognitive symptoms of depression, and to evaluate the mediating role of quality of life (QOL) domains on this effectiveness.
Thirty-one female outpatients suffering from major depressive disorder aged 20-50 years were divided into intervention (n = 15) and control (n = 16) groups. The intervention group received an aerobic exercise program consisting of 36 one-hour sessions, three times a week in the gym with an intensity of 50–70% maximum heart rate and the control group received only routine treatment. Beck Depression Inventory-II and the World Health Organization Quality of Life-BREF questionnaire were used.
Post-intervention results showed a significant reduction in the intensity of the three somatic (p < 0.001), affective (p < 0.001) and cognitive (p < 0.013) symptoms of depression and a significant improvement in the psychological health (p < 0.002) and social relationships (p < 0.003) domains of QOL in the intervention group compared with the control group. No significant difference was found in other domains of QOL between the two groups.
Aerobic exercise, as a multi-dimensional adjunctive treatment along with routine care, can further improve all three categories of somatic, affective, and cognitive symptoms of depression, especially by enhancing the psychological health and social relationships domains of QOL.
KeywordsAerobic exercise Major depressive disorder Quality of life Psychological health
The authors would like to thank the president and personnel of Bahman Psychiatric Hospital in Yazd, Iran for their support.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
This study was approved by the ethics committee of Mashhad University of Medical Sciences (Register Code: IR.MUMS.REC.1395.6), and was registered as a clinical trial in the Iranian Registry of Clinical Trials (http://www.irct.ir, Register Code: IRCT2016082929598N1).
Informed consent was obtained from all individual participants included in the study.
- 5.Schuch FB, Vasconcelos-Moreno MP, Borowsky C, Zimmermann AB, Rocha NS, Fleck MP (2015) Exercise and severe major depression: effect on symptom severity and quality of life at discharge in an inpatient cohort. J Psychiatry Res 61:25–32. https://doi.org/10.1016/j.jpsychires.2014.11.005 CrossRefGoogle Scholar
- 7.Pilu A, Sorba M, Hardoy M, Floris A, Mannu F, Seruis M, Velluti C, Carpiniello B, Salvi M, Carta M (2007) Efficacy of physical activity in the adjunctive treatment of major depressive disorders: preliminary results. Clin Pract Epidemiol Ment Health 3(1):8. https://doi.org/10.1186/1745-0179-3-8 CrossRefPubMedPubMedCentralGoogle Scholar
- 13.Sylvia LG, Friedman ES, Kocsis JH, Bernstein EE, Brody BD, Kinrys G, Kemp DE, Shelton RC, McElroy SL, Bobo WV, Kamali M, McInnis MG, Tohen M, Bowden CL, Ketter TA, Deckersbach T, Calabrese JR, Thase ME, Reilly-Harrington NA, Singh V, Rabideau DJ, Nierenberg AA (2013) Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder. J Affect Disord 151:722–727. https://doi.org/10.1016/j.jad.2013.07.031 CrossRefPubMedGoogle Scholar
- 15.Morres ID, Hatzigeorgiadis A, Stathi A, Comoutos N, Arpin-Cribbie C, Krommidas C, Theodorakis Y (2019) Aerobic exercise for adult patients with major depressive disorder in mental health services: a systematic review and meta-analysis. Depress Anxiety 36:39–53. https://doi.org/10.1002/da.22842 CrossRefPubMedGoogle Scholar
- 18.Murri MB, Ekkekakis P, Menchetti M, Neviani F, Trevisani F, Tedeschi S, Latessa PM, Nerozzi E, Ermini G, Zocchi D, Squatrito S, Toni G, Cabassi A, Neri M, Zanetidou S, Amore M (2018) Physical exercise for late-life depression: effects on symptom dimensions and time course. J Affect Disord 230:65–70. https://doi.org/10.1016/j.jad.2018.01.004 CrossRefPubMedGoogle Scholar
- 19.Schuch FB, Vancampfort D, Rosenbaum S, Richards J, Ward PB, Stubbs B (2016) Exercise improves physical and psychological quality of life in people with depression: a meta-analysis including the evaluation of control group response. Psychiatry Res 241:47–54. https://doi.org/10.1016/j.psychres.2016.04.054 CrossRefPubMedGoogle Scholar
- 24.Aigner M, Forster-Streffleur S, Prause W, Freidl M, Weiss M, Bach M (2006) What does the WHOQOL-Bref measure? Measurement overlap between quality of life and depressive symptomatology in chronic somatoform pain disorder. Soc Psychiatry Psychiatr Epidemiol 41:81–86. https://doi.org/10.1007/s00127-005-0997-8 CrossRefPubMedGoogle Scholar
- 27.American College of Sports Medicine (2010) ACSM’s guidelines for exercise testing and prescription, 8th edn. Wolters Kluwer/Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
- 29.Nedjat S, Montazeri A, Holakouie K, Mohammad K, Majdzadeh R (2008) Psychometric properties of the Iranian interview-administered version of the World Health Organization’s Quality of Life Questionnaire (WHOQOL-BREF): a population-based study. BMC Health Serv Res 8:61. https://doi.org/10.1186/1472-6963-8-61 CrossRefPubMedPubMedCentralGoogle Scholar
- 34.Wijndaele K, Matton L, Duvigneaud N, Lefevre J, De Bourdeaudhuij I, Duquet W, Thomis M, Philippaerts RM (2007) Association between leisure time physical activity and stress, social support and coping: a cluster-analytical approach. Psychol Sport Exerc 8:425–440. https://doi.org/10.1016/j.psychsport.2006.08.001 CrossRefGoogle Scholar
- 40.Elavsky S, McAuley E, Motl RW, Konopack JF, Marquez DX, Hu L, Jerome GJ, Diener E (2005) Physical activity enhances long-term quality of life in older adults: efficacy, esteem, and affective influences. Ann Behav Med 30:138–145. https://doi.org/10.1207/s15324796abm3002_6 CrossRefPubMedGoogle Scholar