Very light physical activity amount in FTO genetically predisposed obese individuals

  • Giuseppe Labruna
  • Maurizio Marra
  • Carmela Nardelli
  • Annamaria Mancini
  • Pasqualina Buono
  • Lucia SacchettiEmail author
  • Fabrizio PasanisiEmail author
Original Article



Fat mass and obesity-related (FTO) rs9939609 polymorphism has a role in body mass index (BMI) increase and in predisposing to metabolic syndrome (MetS). Our aim was to investigate if a very light physical activity could counteract weight gain and MetS in obese subjects bearing the rs9939609 FTO polymorphism from Southern Italy.


Data of fitness components, anthropometry, clinical-biochemical parameters and FTO polymorphism in 78 unrelated morbid obese subjects from Southern Italy (15–30 years) were examined. Physical activity energy expenditure was monitored by a SenseWear Pro 3 Armband for 24 h/day for 2 consecutive weekdays in all enrolled individuals.


Sedentary obese subjects had higher waist circumference (124.8 vs 117.9 cm, P < 0.05), BMI (43.4 vs 37.7 kg/m2, P < 0.0001) and fat mass (49.2 vs 44.5%, P < 0.0001) compared to lightly active ones. Further, lightly active obese subjects bearing the rs9939609 FTO minor allele had a lower BMI than polymorphic sedentary ones (37.1 vs 45.3 kg/m2, respectively, P < 0.01), and did not differ in metabolic syndrome presence.


Our results suggest that a very light amount of physical exercise is associated with a lower BMI in obese subjects bearing the minor allele of the rs9939609 FTO polymorphism.


Very light intensity exercise Obesity BMI FTO polymorphism Metabolic syndrome 



Pasqualina Buono was supported by the University of Naples “Parthenope” under grants “Bando per la Ricerca competitiva, triennio 2016-18 quota C” and “Fondo per la ricerca individuale di Ateneo, Annualità 2016″. Grants: Progetto Regione Campania SATIN to Lucia Sacchetti.

Compliance with ethical standards

Conflicts of interest

The authors declare no conflict of interest.

Ethical approval

All procedures were in accord with current national and international laws and regulations governing in line with the Declaration of Helsinki.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2019

Authors and Affiliations

  1. 1.IRCCS SDNNaplesItaly
  2. 2.Dipartimento di Medicina Clinica e ChirurgiaUniversità degli Studi di Napoli Federico IINaplesItaly
  3. 3.Dipartimento di Medicina Molecolare e Biotecnologie MedicheUniversità degli Studi di Napoli Federico IINaplesItaly
  4. 4.CEINGE-Biotecnologie AvanzateNaplesItaly
  5. 5.Dipartimento di Scienze Motorie e del BenessereUniversità degli Studi di Napoli ParthenopeNaplesItaly

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