Very light physical activity amount in FTO genetically predisposed obese individuals
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Fat mass and obesity-related (FTO) rs9939609 polymorphism has a role in body mass index (BMI) increase and in predisposing to metabolic syndrome (MetS). Our aim was to investigate if a very light physical activity could counteract weight gain and MetS in obese subjects bearing the rs9939609 FTO polymorphism from Southern Italy.
Data of fitness components, anthropometry, clinical-biochemical parameters and FTO polymorphism in 78 unrelated morbid obese subjects from Southern Italy (15–30 years) were examined. Physical activity energy expenditure was monitored by a SenseWear Pro 3 Armband for 24 h/day for 2 consecutive weekdays in all enrolled individuals.
Sedentary obese subjects had higher waist circumference (124.8 vs 117.9 cm, P < 0.05), BMI (43.4 vs 37.7 kg/m2, P < 0.0001) and fat mass (49.2 vs 44.5%, P < 0.0001) compared to lightly active ones. Further, lightly active obese subjects bearing the rs9939609 FTO minor allele had a lower BMI than polymorphic sedentary ones (37.1 vs 45.3 kg/m2, respectively, P < 0.01), and did not differ in metabolic syndrome presence.
Our results suggest that a very light amount of physical exercise is associated with a lower BMI in obese subjects bearing the minor allele of the rs9939609 FTO polymorphism.
KeywordsVery light intensity exercise Obesity BMI FTO polymorphism Metabolic syndrome
Pasqualina Buono was supported by the University of Naples “Parthenope” under grants “Bando per la Ricerca competitiva, triennio 2016-18 quota C” and “Fondo per la ricerca individuale di Ateneo, Annualità 2016″. Grants: Progetto Regione Campania SATIN to Lucia Sacchetti.
Compliance with ethical standards
Conflicts of interest
The authors declare no conflict of interest.
All procedures were in accord with current national and international laws and regulations governing in line with the Declaration of Helsinki.
Informed consent was obtained from all individual participants included in the study.
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