Sport Sciences for Health

, Volume 15, Issue 1, pp 249–253 | Cite as

Restoring knee joint kinematics after anterior cruciate ligament injury might inhibit synovial membrane inflammation

  • Kenji MurataEmail author
  • Takanori Kokubun
  • Kiyomi Takayanagi
  • Naohiko Kanemura
Short Communication


We developed a novel controlled abnormal joint movement (CAJM) model that controls instability after traditional anterior cruciate ligament transection (ACL-T). We evaluated whether joint instability damping suppresses synovial inflammation in osteoarthritis patients using our new CAJM rat model. We found that joint instability in rats differed between the ACL-T and CAJM models. Joint instability might contribute to synovitis and inhibit osteoarthritis.


Joint kinematics Synovitis Knee Rat model 





Anterior cruciate ligament


ACL transection


Controlled abnormal joint movement


Matrix metalloproteinase


A disintegrin and metalloproteinase with thrombospondin motifs



We would like to thank Kassuya Onitsuka (Tokyo Women’s Medical University, Yachiyo Medical Center), Namine Kiso (Saitama Sekishinkai Hospital), Yoko Sirose (Yokohama Rosai Hospital), and Nozomi Kuwabara (Graduate School of Saitama Prefectural University) for their assistance with the surgery and sample collection. This study was supported by a JSPS KAKENHI (26560278) Grant in-Aid for Challenging Exploratory Research.


This study was funded by a JSPS KAKENHI (26560278) Grant in-Aid for Challenging Exploratory Research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The Ethics Committee of Saitama Prefectural University approved all procedures (approval number: 27-6). All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed consent

Informed consent is not applicable for this study.


  1. 1.
    Murata K, Kanemura N, Kokubun T, Fujino T, Morishita Y, Onitsuka K, Fujiwara S, Nakajima A, Shimizu D, Takayanagi K (2017) Controlling joint instability delays the degeneration of articular cartilage in a rat model. Osteoarthr Cartil 25:297–308CrossRefGoogle Scholar
  2. 2.
    Kokubun T, Kanemura N, Murata K, Moriyama H, Morita S, Jinno T, Ihara H, Takayanagi K (2016) Effect of changing the joint kinematics of knees with a ruptured anterior cruciate ligament on the molecular biological responses and spontaneous healing in a rat model. Am J Sports Med 44:2900–2910CrossRefGoogle Scholar
  3. 3.
    Mathiessen A, Conaghan PG (2017) Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther 19:18CrossRefGoogle Scholar
  4. 4.
    Scanzello CR, Goldring SR (2012) The role of synovitis in osteoarthritis pathogenesis. Bone 51(2):249–257CrossRefGoogle Scholar
  5. 5.
    Egloff C, Hart DA, Hewitt C, Vavken P, Valderrabano V, Herzog W (2016) Joint instability leads to long-term alterations to knee synovium and osteoarthritis in a rabbit model. Osteoarthr Cartil 24(6):1054–1060CrossRefGoogle Scholar
  6. 6.
    Hada S, Ishijima M, Kaneko H, Kinoshita M, Liu L, Sadatsuki R, Shiozawa J (2017) Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis. Arthritis Res Ther 19(1):201CrossRefGoogle Scholar
  7. 7.
    Hsia AW, Anderson MJ, Heffner MA, Lagmay EP, Zavodovskaya R, Christiansen BA (2017) Osteophyte formation after ACL rupture in mice is associated with joint restabilization and loss of range of motion. J Orthopaedic Res 35(3):466–473CrossRefGoogle Scholar
  8. 8.
    Lewek MD, Rudolph KS, Snyder-Mackler L (2004) Control of frontal plane knee laxity during gait in patients with medial compartment knee osteoarthritis. Osteoarthr Cartil 12:745–751CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Therapy, School of Health and Social ServicesSaitama Prefectural UniversityKoshigayaJapan

Personalised recommendations