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Altered sleep quality is associated with Crohn’s disease activity: an actimetry study

  • Thomas Bazin
  • Jean-Arthur Micoulaud Franchi
  • Nathalie Terras
  • Jacques Taillard
  • David Laharie
  • Frank Zerbib
  • Pierre PhilipEmail author
Sleep Breathing Physiology and Disorders • Original Article
  • 9 Downloads

Abstract

Background

Sleep is involved in the regulation of inflammation, healing, and digestion. The pathophysiology of Crohn’s disease (CD) is unclear, and the role of sleep disturbances has recently been suggested.

Objective

The present study investigated a putative association between sleep disturbances and CD activity.

Methods

We conducted a prospective observational monocenter translational study, recruiting major CD patients from 2013 to 2015. Disease activity was assessed by the Harvey-Bradshaw index and the CD activity index. Objective sleep quantity and quality were measured by wrist actigraphy over a period of 7 days. The primary objective was to look for an association between wrist actigraphy parameters and CD activity.

Results

Thirty-four CD patients, including 14 with active disease and 20 in remission, were included. Sleep efficiency measured by wrist actigraphy was lower in patients with active CD compared to patients in remission. Wake after sleep onset time best predicted CD activity with an AUROC of 0.83. Patients with active CD were more frequently characterized as “poor sleepers” and frequently suffered from excessive daytime sleepiness.

Conclusion

Sleep efficiency is lower in patients with active CD than in those in remission. Further studies aimed at better characterizing CD patients’ sleep are warranted.

Keywords

Crohn’s disease Wrist actigraphy Sleep quality 

Notes

Acknowledgments

We thank the clinical research associates from the gastroenterology department and GENPHASS.

Compliance with ethical standards

Conflict of interest

The authors declare that they no conflict of interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University of Bordeaux, INRA, EA 3671, CHU BordeauxBordeauxFrance
  2. 2.Gastroenterology and Hepatology Department, Hôpital Haut LévêqueCentre Hospitalier Universitaire de Bordeaux and Université de BordeauxBordeauxFrance
  3. 3.University Bordeaux, CNRS, SANPSY, USR 3413BordeauxFrance
  4. 4.Bordeaux Hospital University CenterClinique du sommeilBordeauxFrance
  5. 5.GENPPHASS, Hôpital Pellegrin, Tripode 13ème Etage, Place Amélie Raba LéonBordeaux CEDEXFrance

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