Association of serum adiponectin level with cystatin C in male patients with obstructive sleep apnea syndrome

  • Dong-Dong ChenEmail author
  • Jie-Feng Huang
  • Song-Ping Huang
  • Xiao-Fang Chen
Sleep Breathing Physiology and Disorders • Original Article



Obstructive sleep apnea syndrome (OSAS) was suggested to exert an effect on renal function. However, the specific mechanism was still unknown. We try to find the association among OSAS, adiponectin, and cystatin C and the effect of adiponectin on renal function in OSAS patients.


Seventeen healthy men and seventy-three men which only had OSAS were included in the end. Apnea-hypopnea index (AHI), oxygen desaturation index (ODI), the percentage of total sleep time spent with SpO2 < 90% (T90%), lowest O2 saturation (LaSO2), Epworth Sleepiness Scale (ESS) score, serum adiponectin, and high-sensitive C-reactive protein (hsCRP) were detected in all subjects, and renal function was evaluated with creatinine, cystatin C, and estimated glomerular filtration rate (eGFR).


Demographic data, creatinine, and eGFR did not differ among the studied groups. Decreased serum adiponectin levels were associated with severe OSAS. OSAS patients had a higher hsCRP and cystatin C than those without OSAS. Serum adiponectin levels had a negative association with cystatin C. After adjusted for confounders, adiponectin, hsCRP, and ODI had a significant prediction on the cystatin C (β = − 0.218, p = 0.011; β = 0.226, p = 0.037; and β = 0.231, p = 0.029).


Decreased serum adiponectin was associated with increased cystatin C in male OSAS patients. These results suggest that serum adiponectin might be a regulatory factor for renal function in OSAS.


Obstructive sleep apnea syndrome Adiponectin Cystatin C 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Respiratory MedicineQuanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhouChina
  2. 2.Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease of the Fujian Medical University, Department of Respiratory Medicinethe First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

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