Response to: Letter to the Editors: Re: Simultaneous PET/MRI in the Evaluation of Breast and Prostate Cancer Using Combined Na[18F]F and [18F]FDG: A Focus on Skeletal Lesions
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We thank Dr. Høilund-Carlsen and Dr. Alavi for their interest in our article . The authors wrote that the combined Na[18F]F/[18F]FDG PET/MRI approach used in our study can be an overkill causing more confusion than clarity . The reason for this confusion seems to be the high sensitivity of Na[18F]F, which may identify cancer-like foci in case of microcalcification caused by other conditions than malignancy. The authors reference two case reports to support their argument [3, 4]; Na[18F]F uptake was described in both of their cases in noncancerous calcifications of the tracheobronchial tree and of a uterine leiomyoma, respectively.
AI receives institutional grants from GE Healthcare, Advanced Accelerator Applications, and Progenics Pharmaceuticals.
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Conflict of Interest
The authors declare that they have no conflict of interest.
- 1.Sonni I, Minamimoto R, Baratto L, Gambhir SS, Loening AM, Vasanawala SS, Iagaru A (2019) Simultaneous PET/MRI in the evaluation of breast and prostate cancer using combined Na[18F] F and [18F]FDG: a focus on skeletal lesions. Mol Imaging Biol doi:1–10. https://doi.org/10.1007/s11307-019-01392-9
- 2.Hoilund-Carlsen PF, Alavi A (2019) Letter to the editor: simultaneous PET/MRI in the evaluation of breast and prostate cancer using combined Na[18F] F and [18F]FDG: a focus on skeletal lesions. Mol Imaging Biol doi:1–2. https://doi.org/10.1007/s11307-019-01449-9