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Half-Time SPECT Acquisition with Resolution Recovery for Tc-MIBI SPECT Imaging in the Assessment of Hyperparathyroidism

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Abstract

Purpose

Reduced SPECT acquisition time protocols have been recently developed based on collimator-detector response compensation reconstruction. The present study aims to evaluate the potential use of a short-time technetium-99m methoxyisobutylisonitrile (Tc99m-MIBI) SPECT algorithm in the investigation of parathyroid adenoma (PTA).

Procedures

Ninety patients (59 women; age range, 21–76 years) with biochemical evidence of hyperparathyroidism were referred for Tc99m-MIBI scintigraphy for diagnosis and localization of PTA. Standard full-time and half-time SPECT studies starting at 45 min after injection were performed in random order in all patients. PTA detection rate and overall image quality parameters were evaluated and graded for each study and compared for the two SPECT protocols.

Results

Focal 99mTc-sestamibi uptake consistent with PTA was reported in 60 out of 90 studies (67%). Congruent results between the full- and half-time SPECT acquisition were found in 73 patients (81%). Minor disagreement between the two SPECT protocols with respect to PTA detectability was found in 17 patients but with no statistically significant difference (p = 0.67). The correlation coefficient between the two SPECTs was r = 0.88 (p < 0.0001), and the Bland–Altman correlation analysis confirmed the interchangeability of the two protocols. Image quality was reported as either good or excellent for all studies, and no statistical significant difference in image quality scoring between protocols was found (p = 0.155).

Conclusion

Parathyroid MIBI SPECT can be performed using the collimator-detector response compensation reconstruction algorithm for only half of the scanning time without compromising significant diagnostic data.

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References

  1. Frey E, Tsui B (2005) Collimator-detector response compensation in SPECT. In: Zaidi H (ed) Quantitative analysis in nuclear medicine imaging. Springer, New York, pp 141–166

    Google Scholar 

  2. Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG (2009) Half-time SPECT myocardial perfusion imaging with attenuation correction. J Nucl Med 50:554–562

    Article  PubMed  Google Scholar 

  3. Keidar Z, Sachs J, Radan R, Volokh L, Shai E, Bar-Shalom R, Israel O (2006) Half-time bone SPECT acquisition assessment of a new collimator detector response (CDR) reconstruction algorithm. J Nucl Med 47(suppl):380

    Google Scholar 

  4. Palestro CJ, Tomas MB, Tronco GG (2005) Radionuclide imaging of the parathyroid glands. Semin Nucl Med 35:266–276

    Article  PubMed  Google Scholar 

  5. Rubello D, Massaro A, Cittadin S, Rampin L, Al-Nahhas A, Boni G, Mariani G, Pelizzo MR (2006) Role of 99mTc-sestamibi SPECT in accurate selection of primary hyperparathyroid patients for minimally invasive radio-guided surgery. Eur J Nucl Med Mol Imaging 33:1091–1094

    Article  PubMed  CAS  Google Scholar 

  6. Sukan A, Reyhan M, Aydin M, Yapar AF, Sert Y, Canpolat T, Aktas A (2008) Preoperative evaluation of hyperparathyroidism: the role of dual-phase parathyroid scintigraphy and ultrasound imaging. Ann Nucl Med 22:123–131

    Article  PubMed  Google Scholar 

  7. Kandil E, Wassef SN, Alabbas H, Freidlander PL (2009) Minimally invasive video-assisted thyroidectomy and parathyroidectomy with intraoperative recurrent laryngeal nerve monitoring. Int J Otolaryngol 2009:739798

    PubMed  Google Scholar 

  8. Shabtai M, Ben-Haim M, Muntz Y, Vered I, Rosin D, Kuriansky J, Zmora O, Olchovski D, Ayalon A, Zwas ST (2003) 140 consecutive cases of minimally invasive, radio-guided parathyroidectomy: lessons learned and long-term results. Surg Endosc 17:688–691

    Article  PubMed  CAS  Google Scholar 

  9. (1991) Proceedings of the NIH Consensus Development Conference on diagnosis and management of asymptomatic primary hyperparathyroidism. Bethesda, Maryland, October 29–31, 1990. J Bone Miner Res 6 Suppl 2:S1–166

  10. Valenta I, Treyer V, Husmann L, Gaemperli O, Schindler MJ, Herzog BA, Veit-Heibach P, Buechel RR, Nkoulou R, Pazhenkottil AP, Kaufmann PA (2010) New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging 37:750–757

    Article  PubMed  Google Scholar 

  11. Lavely WC, Goetze S, Friedman KP, Leal JP, Zhang Z, Garret-Mayer E, Dackiw AP, Tufano RP, Zeiger MA, Ziessman HA (2007) Comparison of SPECT/CT, SPECT, and planar imaging with single- and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy. J Nucl Med 48:1084–1089

    Article  PubMed  Google Scholar 

  12. Notghi A, O’Brien J, Clarke EA, Thomson WH (2010) Acquiring diagnostic DaTSCAN images in claustrophobic or difficult patients using a 180 degrees configuration. Nucl Med Commun 31:217–226

    Article  PubMed  Google Scholar 

  13. Venero CV, Heller GV, Bateman TM, McGhie AI, Ahlberg AW, Katten D, Courter SA, Golub RJ, Case JA, Cullom SJ (2009) A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol 16:714–725

    Article  PubMed  Google Scholar 

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Conflicts of Interest

All authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel

    Ronen Bar & Avishay Golz

  2. Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel

    Kinga Przewloka, Rachel Karry, Alex Frenkel & Zohar Keidar

  3. B. and R. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Avishay Golz & Zohar Keidar

Authors
  1. Ronen Bar
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  2. Kinga Przewloka
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  3. Rachel Karry
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  4. Alex Frenkel
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  5. Avishay Golz
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  6. Zohar Keidar
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Corresponding author

Correspondence to Zohar Keidar.

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Bar, R., Przewloka, K., Karry, R. et al. Half-Time SPECT Acquisition with Resolution Recovery for Tc-MIBI SPECT Imaging in the Assessment of Hyperparathyroidism. Mol Imaging Biol 14, 647–651 (2012). https://doi.org/10.1007/s11307-011-0530-2

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  • DOI: https://doi.org/10.1007/s11307-011-0530-2

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