Advertisement

Single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction: preliminary study on diagnostic ability of maximum standardized uptake value

  • Kazunori Ninomiya
  • Shuji Toya
  • Ichiro OguraEmail author
Original Article
  • 10 Downloads

Abstract

Objectives

The aim of this study was to investigate of salivary gland dysfunction with single-photon emission computed tomography/computed tomography (SPECT/CT), especially the relationship between maximum standardized uptake value (SUVmax) of salivary glands and their dysfunction.

Methods

Five patients (2 submandibular sialolithiasis, 2 Sjögren's syndrome, and 1 parotitis) who underwent SPECT/CT were included in this study. The salivary gland excretion function was defined as A (pre-stimulatory 20 min after injection of Tc-99m pertechnetate)/B (post-stimulatory 40 min after injection of Tc-99m pertechnetate) using SUVmax of parotid and submandibular glands.

Results

SUVmax before stimulation of the submandibular gland with sialoliths in a patient was lower than that in the opposite submandibular gland without sialoliths (5.81 vs 51.37). Furthermore, the A/B using SUVmax in the other patient of submandibular glands with sialoliths was lower than that in the opposite submandibular glands without sialoliths (0.70 vs 1.85). The A/B using SUVmax of right and left parotid gland in a patient with Sjögren's syndrome was 1.06 and 0.74, respectively. Furthermore, the A/B using SUVmax of right and left parotid glands in the other patient with Sjögren's syndrome was 3.20 and 4.32, respectively. The A/B using SUVmax of right and left parotid glands in a patient with left parotitis was 2.26 and 1.58, respectively.

Conclusion

The results of the present study indicate that SUVmax using SPECT/CT seems a useful tool for evaluation of the salivary gland dysfunction.

Keywords

SPECT/CT Salivary gland Sialolithiasis Parotitis Sjögren's syndrome 

Notes

Acknowledgements

This work was supported by JSPS KAKENHI Grant Number JP 18K09754.

Compliance with ethical standards

Conflict of interest

Kazunori Ninomiya, Shuji Toya, and Ichiro Ogura declare that they have no conflict of interest.

Human rights statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5).

Informed consent

Informed consent was obtained from all patients for being included in the study.

References

  1. 1.
    Kim JH, Aoki EM, Cortes AR, Abdala-Junior R, Asaumi J, Arita ES. Comparison of the diagnostic performance of panoramic and occlusal radiographs in detecting submandibular sialoliths. Imaging Sci Dent. 2016;46:87–92.CrossRefGoogle Scholar
  2. 2.
    Lustmann J, Regev E, Melamed Y. Sialolithiasis. A survey on 245 patients and a review of the literature. Int J Oral Maxillofac Surg. 1990;19:135–8.CrossRefGoogle Scholar
  3. 3.
    Schwarz D, Kabbasch C, Scheer M, Mikolajczak S, Beutner D, Luers JC. Comparative analysis of sialendoscopy, sonography, and CBCT in the detection of sialolithiasis. Laryngoscope. 2015;125:1098–101.CrossRefGoogle Scholar
  4. 4.
    Ogura I, Sasaki Y, Oda T, Sue M, Hayama K. Magnetic resonance sialography and salivary gland scintigraphy of parotid glands in Sjögren's syndrome. Chin J Dent Res. 2018;21:63–8.Google Scholar
  5. 5.
    Gulati A, Scott J, Blythe JN, Southorn B, Brennan PA. Review of salivary papers published in the British Journal of Oral and Maxillofacial Surgery during 2009–2010. Br J Oral Maxillofac Surg. 2011;49:627–9.CrossRefGoogle Scholar
  6. 6.
    Wu CB, Xi H, Zhou Q, Zhang LM. The diagnostic value of technetium 99m pertechnetate salivary gland scintigraphy in patients with certain salivary gland diseases. J Oral Maxillofac Surg. 2015;73:443–50.CrossRefGoogle Scholar
  7. 7.
    Ogura I, Hayama K, Sue M, Oda T, Sasaki Y. Submandibular sialolithiasis with CT and scintigraphy: CT values and salivary gland excretion in the submandibular glands. Imaging Sci Dent. 2017;47:227–31.CrossRefGoogle Scholar
  8. 8.
    Suh MS, Lee WW, Kim YK, Yun PY, Kim SE. Maximum standardized uptake value of 99mTc hydroxymethylene diphosphonate SPECT/CT for the evaluation of temporomandibular joint disorder. Radiology. 2016;280:890–6.CrossRefGoogle Scholar
  9. 9.
    Kaneta T, Ogawa M, Daisaki H, Nawata S, Yoshida K, Inoue T. SUV measurement of normal vertebrae using SPECT/CT with Tc-99m methylene diphosphonate. Am J Nucl Med Mol Imaging. 2016;22:262–8.Google Scholar
  10. 10.
    Kim J, Lee H, Lee H, Bang JI, Kang YK, Bae S, et al. Quantitative single-photon emission computed tomography/computed tomography for evaluation of salivary gland dysfunction in Sjögren's syndrome patients. Nucl Med Mol Imaging. 2018;52:368–76.CrossRefGoogle Scholar
  11. 11.
    Jardim EC, Ponzoni D, de Carvalho PS, Demetrio MR, Aranega AM. Sialolithiasis of the submandibular gland. J Craniofac Surg. 2011;22:1128–31.CrossRefGoogle Scholar
  12. 12.
    Chen J, Zhao X, Liu H, Zhou S, Yang Y, Li S, et al. A point-scoring system for the clinical diagnosis of Sjögren's syndrome based on quantified SPECT imaging of salivary gland. PLoS ONE. 2016;11:e0155666.CrossRefGoogle Scholar
  13. 13.
    Araz M, Soydal C, Ozkan E, Kir MK, Ibis E, Gullu S, et al. The efficacy of fluorine-18-choline PET/CT in comparison with 99m Tc-MIBI SPECT/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism. Nucl Med Commun. 2018;39:989–94.CrossRefGoogle Scholar

Copyright information

© Japanese Society for Oral and Maxillofacial Radiology and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Comprehensive Dental CareThe Nippon Dental University Niigata HospitalNiigataJapan
  2. 2.Oral and Maxillofacial Surgery, Dry Mouth ClinicThe Nippon Dental University Niigata HospitalNiigataJapan
  3. 3.Department of Oral and Maxillofacial RadiologyThe Nippon Dental University School of Life Dentistry at NiigataNiigataJapan

Personalised recommendations