Oral Radiology

, Volume 34, Issue 3, pp 229–236 | Cite as

Case–control study of mandibular canal branching and tooth-related inflammatory lesions

  • Mauricio Augusto Aquino CastroEmail author
  • Manuel Oscar Lagravere Vich
  • Mauro Henrique Guimaraes Abreu
  • Ricardo Alves Mesquita
Original Article



Morphological variations of mandibular canals increase the risk of neurovascular damage and bleeding during surgical procedures by decreasing the predictability of the inferior alveolar neurovascular bundle location. To improve the predictability with such variations, the present study aimed to verify the possibility of a relationship between mandibular canal branches (MCBs) and tooth-related inflammatory lesions, using trough cone-beam computed tomography (CBCT) examinations.


The sample comprised 150 age and sex-matched examinations (50 cases and 100 controls) from two databases. The CBCT examinations were grouped by the presence of MCBs starting in the mandibular body regions as the outcome variable. Tooth-related inflammatory lesions and measurements of gray levels in the posterior region of the alveolar ridge were assessed in both groups. A multiple logistic regression analysis was applied to verify the relationships between MCBs and independent variables (p < 0.05).


Occurrence of tooth-related inflammatory lesions increased the risk of MCBs in the mandibular body regions (p < 0.001; OR 11.640; 95% CI 4.327–31.311). High-contrast images had a weaker association with MCBs (p = 0.002; OR 1.002; 95% CI 1.002–1.003). The most frequent tooth-related inflammatory lesions in both groups were endodontic (34 lesions; 45.94% of the total lesions). Most of the tooth-related inflammatory lesions related to MCBs were endodontic (20 cases) and combined endodontic and periodontal inflammation (20 cases).


An association was observed between MCBs in the mandibular body regions and tooth-related inflammatory lesions. Inflammatory lesions of endodontic origin are most often associated with MCBs.


Cone-beam computed tomography Mandibular canal Oral pathology 


Compliance with ethical standards

Conflict of interest

Mauricio Augusto Aquino Castro, Manuel Oscar Lagravere Vich, Mauro Henrique Guimaraes Abreu, and Ricardo Alves Mesquita declare that they have no conflict of interest.

Human rights statements and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Japanese Society for Oral and Maxillofacial Radiology and Springer Japan KK 2017

Authors and Affiliations

  • Mauricio Augusto Aquino Castro
    • 1
    Email author
  • Manuel Oscar Lagravere Vich
    • 2
  • Mauro Henrique Guimaraes Abreu
    • 3
  • Ricardo Alves Mesquita
    • 4
  1. 1.Department of DentistryFederal University of Juiz de ForaGovernador ValadaresBrazil
  2. 2.Graduate Orthodontic ProgramUniversity of AlbertaEdmontonCanada
  3. 3.Department of Community and Preventive DentistryFederal University of Minas GeraisBelo HorizonteBrazil
  4. 4.Department of Oral Surgery and PathologyFederal University of Minas GeraisBelo HorizonteBrazil

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