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Oral Radiology

, Volume 34, Issue 3, pp 262–266 | Cite as

Radiological manifestations of renal osteodystrophy in the orofacial region: a case report and literature review

  • Meng You
  • Bei Tang
  • Zi-jiang Wang
  • Kai-li Wang
  • Hu Wang
Case Report
  • 140 Downloads

Abstract

Renal osteodystrophy (ROD) is a metabolic skeletal pathology that frequently affects the orofacial region and presents with characteristic radiological manifestations. This paper reports a case of ROD causing diffused orofacial bone alterations in a female patient with end-stage chronic kidney disease. The radiological features on panoramic, posteroanterior and lateral skull and computed tomography radiographs are described for this case. Previous reports in the literature are reviewed and discussed with a focus on radiological characteristics and differential diagnoses.

Keywords

Renal osteodystrophy Oral and maxillofacial manifestations Radiological diagnosis 

Notes

Acknowledgements

Funding was provided by National Science Foundation of China (Grant No. 31600400) and The College Funding of West China College of Stomatology.

Compliance with ethical standards

Conflict of interest

Meng You, Bei Tang, Zi-jiang Wang, Kai-li Wang, and Hu Wang declare that they have no conflict of interest.

Human rights statement and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from the patient for being included in the study.

References

  1. 1.
    Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD–MBD). Kidney Int Suppl. 2009;113:S1–130.Google Scholar
  2. 2.
    Jevtic V. Imaging of renal osteodystrophy. Eur J Radiol. 2003;46:85–95.CrossRefPubMedGoogle Scholar
  3. 3.
    Fatahzadeh M. The spectrum of orofacial manifestations in renal osteodystrophy: diagnostic challenges of an uncommon presentation. Quintessence Int. 2011;42:e78–88.PubMedGoogle Scholar
  4. 4.
    Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382:260–72.CrossRefPubMedGoogle Scholar
  5. 5.
    Parthiban J, Aarthi Nisha V, Asokan G, Prakash C, Varadharaja M. Oral manifestations in a renal osteodystrophy patient—a case report with review of literature. J Clin Diagn Res. 2014;8:ZD28–30.Google Scholar
  6. 6.
    Proctor R, Kumar N, Stein A, Moles D, Porter S. Oral and dental aspects of chronic renal failure. J Dent Res. 2005;84:199–208.CrossRefPubMedGoogle Scholar
  7. 7.
    Liebross BA, Coburn JW. Renal osteodystrophy. Clin Endocrinol. 2013;2:151–88.Google Scholar
  8. 8.
    Vaishya R, Nyokabi DN, Vaish A. Bilateral hip arthritis in a case of renal osteodystrophy. BMJ Case Rep. 2014. doi: 10.1136/bcr-2013-201420 Google Scholar
  9. 9.
    Civitelli R, Hildebolt C. Oral manifestations of metabolic bone diseases. Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th ed. New Jersey: Wiley; 2013. p. 948–58.CrossRefGoogle Scholar
  10. 10.
    Lopes ML, Albuquerque AF, Germano AR, Queiroz LM, Miguel MC, da Silveira EJ. Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease. Oral Maxillofac Surg. 2015;19:321–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Chang JI, Som PM, Lawson W. Unique imaging findings in the facial bones of renal osteodystrophy. AJNR Am J Neuroradiol. 2007;28:608–9.PubMedGoogle Scholar
  12. 12.
    Collum J, Jones RH, Lynham A, Hirst J. Leontiasis ossea: a presentation of hyperparathyroidism in an indigenous Australian man secondary to chronic renal failure. J Oral Maxillofac Surg. 2013;71:56–61.CrossRefPubMedGoogle Scholar
  13. 13.
    Raubenheimer EJ, Noffke CE, Mohamed A. Expansive jaw lesions in chronic kidney disease: review of the literature and a report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:340–5.CrossRefPubMedGoogle Scholar
  14. 14.
    Sagliker Y, Balal M, Sagliker Ozkaynak P, Paydas S, Sagliker C, Sabit Sagliker H, et al. Sagliker syndrome: uglifying human face appearance in late and severe secondary hyperparathyroidism in chronic renal failure. Semin Nephrol. 2004;24:449–55.CrossRefPubMedGoogle Scholar
  15. 15.
    Sagliker Y, Acharya V, Ling Z, Golea O, Sabry A, Eyupoglu K, et al. International study on Sagliker syndrome and uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic kidney disease patients. J Ren Nutr. 2008;18:114–7.CrossRefPubMedGoogle Scholar
  16. 16.
    Chen XH, Shen B, Zou J, Ding X, Liu Z, Lv W, et al. Clinical status of Sagliker syndrome: a case report and literature review. Ren Fail. 2014;36:800–3.CrossRefPubMedGoogle Scholar
  17. 17.
    Haroyan H, Bos A, Ginat DT. Uremic leontiasis ossea. Am J Otolaryngol. 2015;36:74–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Jalali P, Kim S. Multiple periradicular radiolucencies mimicking endodontic lesions in renal osteodystrophy of the mandible: a case report. Int Endod J. 2016;49:706–14.CrossRefPubMedGoogle Scholar
  19. 19.
    Yang G, Zhang B, Zha X, Wang N, Xing C. Total parathyroidectomy with autotransplantation for a rare disease derived from uremic secondary hyperparathyroidism, the uremic leontiasis ossea. Osteoporos Int. 2014;25:1115–21.CrossRefPubMedGoogle Scholar
  20. 20.
    Razek AAKA. Computed tomography and magnetic resonance imaging of maxillofacial lesions in renal osteodystrophy. J Craniofac Surg. 2014;25:1354–7.CrossRefPubMedGoogle Scholar
  21. 21.
    Atalar MH, Salk I, Savas R, Uysal IO, Egilmez H. CT and MR imaging in a large series of patients with craniofacial fibrous dysplasia. Pol J Radiol. 2015;80:232–40.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Theodorou DJ, Theodorou SJ, Kakitsubata Y. Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 2011;196(6 Suppl):S64–75.CrossRefPubMedGoogle Scholar

Copyright information

© Japanese Society for Oral and Maxillofacial Radiology and Springer Japan KK 2017

Authors and Affiliations

  • Meng You
    • 1
  • Bei Tang
    • 1
  • Zi-jiang Wang
    • 2
  • Kai-li Wang
    • 1
  • Hu Wang
    • 1
  1. 1.Department of Oral Radiology and Laboratory of Oral Diseases, West China College of StomatologySichuan UniversityChengduChina
  2. 2.Department of Nursing, West China HospitalSichuan UniversityChengduChina

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