Regulation and metabolic engineering strategies for permeases of Saccharomyces cerevisiae

  • Peng Zhang
  • Qian Chen
  • Guiming Fu
  • linglin Xia
  • Xing HuEmail author


Microorganisms have evolved permeases to incorporate various essential nutrients and exclude harmful products, which assists in adaptation to different environmental conditions for survival. As permeases are directly involved in the utilization of and regulatory response to nutrient sources, metabolic engineering of microbial permeases can predictably influence nutrient metabolism and regulation. In this mini-review, we have summarized the mechanisms underlying the general regulation of permeases, and the current advancements and future prospects of metabolic engineering strategies targeting the permeases in Saccharomyces cerevisiae. The different types of permeases and their regulatory mechanisms have been discussed. Furthermore, methods for metabolic engineering of permeases have been highlighted. Understanding the mechanisms via which permeases are meticulously regulated and engineered will not only facilitate research on regulation of global nutrition and yeast metabolic engineering, but can also provide important insights for future studies on the synthesis of valuable products and elimination of harmful substances in S. cerevisiae.


Amino acids transport Glucose transport Transporter engineering Metabolic engineering strategies 



This work was supported by the National Natural Science Foundation of China (Grant No. 31801470), Undergraduate Training Program for Innovation and Entrepreneurship of Nanchang University (Grant Nos. 2018303, 20190402112).

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Food Science and TechnologyNanchang UniversityNanchangChina
  2. 2.School of Food Science and TechnologyNanchang UniversityNanchangChina
  3. 3.Department of SoftwareNanchang UniversityNanchangChina

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