Medically important biofilms and non-thermal plasma

  • Jaroslav JulákEmail author
  • Vladimír Scholtz
  • Eva Vaňková


In recent decades, the non-thermal plasma, i.e. partially or completely ionized gas produced by electric discharges at ambient temperature, has become of interest for its microbiocidal properties with potential of use in the food industry or medicine. Recently, this interest focuses not only on the planktonic forms of microorganisms but also on their biofilms. The works in this interdisciplinary field are summarized in this review. The wide range of biofilm-plasma interactions is divided into studies of general plasma action on bacteria, on biofilm and on its oral and dental application; a short overview of plasma instrumentation is also included. In addition, not only biofilm combating but also an important area of biofilm prevention is discussed.

Graphical abstract

Various DC discharges of the point-to-plane type. Author’s photograph, published in Khun et al. (Plasma Sources Sci Technol 27:065002, 2018).


Biofilm inactivation Biofilm prevention Dental and oral Non-thermal plasma production Wound healing 



This research was supported by the Charles University research program Progress Q25.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Institute of Immunology and Microbiology, First Faculty of MedicineCharles University and General University HospitalPrague 2Czech Republic
  2. 2.Department of Physics and MeasurementsUniversity of Chemistry and TechnologyPrague 6Czech Republic
  3. 3.Department of BiotechnologyUniversity of Chemistry and TechnologyPrague 6Czech Republic

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