The synergistic effect of organic acids, phytochemicals and a permeabilizing complex reduces Salmonella Typhimurium 1,4,,12:i-shedding in pigs
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Salmonella Typhimurium (including S.Typhimurium 1,4,,12:i-) and other enteric pathogens cause acute infection in pigs during the weaning stage, often evolving into chronic infections responsible for the introduction of zoonotic bacteria into the slaughterhouse and thus determining carcass contamination. In addition to being zoonotic hazards, these pathogens are responsible for economic losses in affected farms. Traditionally, antibiotic treatments have been largely administered in order to reduce the infection burden but it favored, as a direct consequence, an increase in the number of multi-drug resistance strains. In order to overcome antibiotic-resistance concerns, new alternative control strategies should be developed. In this context, a blend of organic acids, phytochemicals and a permeabilizing complex, administered in feed (Group A - 459 piglets) or water (Group B – 458 piglets), was tested in field conditions for its capability of reducing Salmonella-infection in weaned piglets of an endemic farm. Data recorded were compared to results of a control group (Group C - 456 piglets). Zootechnical parameters were recorded in all animals, while microbiological, serological and PCR analyses were conducted in 15 piglets for each group. Results demonstrated that additive administered in feed improved animal weight gain (better average daily gain [A.D.G.] and increment), and rapidly reduced Salmonella-shedding in feces. Administration of additive in feed gave better results than in water.
KeywordsSalmonella Typhimurium 1,4,,12:i- Organic acids Phytochemicals Swine
average daily gain
all in all out
brilliant green agar
buffered peptone water
feed conversion rate
modified semisolid rappaport-vassiliadis
porcine reproductive and respiratory virus
porcine circovirus type 2
Special thanks to Eurostreet società cooperativa for the English writing assistance.
Compliance with ethical standards
Conflicts of interest
The authors declare that they have no conflict of interest.
Human participants and/or animals
Animals were treated with products that are registered for administration in breeding animals and which the farmer had commonly used. Procedures involving animals were limited to blood and fecal sampling with a ten-day interval. In conclusion, all procedures performed in studies involving animals were in accordance with ethical standards of practice, particularly with those of the National Legislation of Animal Welfare.
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