Androgen-deprivation therapy impairs left ventricle functions in prostate cancer patients
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Androgen-deprivation therapy (ADT) is a treatment option for locally advanced and metastatic prostate cancer (PCA). The aim of the study was to evaluate the effect of ADT on left ventricular (LV) functions assessed by speckle-tracking echocardiography (STE) in prostate cancer (PCA) patients.
Forty-nine consecutive PCA patients (mean age 71.5 ± 6.7 years) who would be treated with radiotherapy and ADT and 32 consecutive PCA patients (mean age 71.9 ± 7.0 years) who would be treated with radical or partial prostatectomy and 42 age-matched healthy men (mean age 70.5 ± 9.1 years) were included in our study. The left ventricular functions were assessed by both conventional echocardiography and STE at baseline and 6 months later.
There were not any significant difference in characteristics of the patients and controls. There were not any significant differences in conventional echocardiographic measures at baseline and at 6th month among the PCA patients and controls. Although there were not any significant differences in STE measures at baseline among the PCA patients and controls, the strain measures of the PCA patients receiving ADT decreased significantly at the 6th month and were significantly lower compared to strain measures of PCA patients undergoing prostatectomy and controls. There was not any statistically significant difference in baseline and 6th-month strain measures of the PCA patients undergoing prostatectomy.
ADT might be associated with decrease in LV longitudinal, circumferential, and radial strain measures in patients with PCA. STE might be useful for early identification of LV subclinical impairment in PCA patients treated with ADT.
KeywordsAndrogen-deprivation therapy Echocardiography Prostate cancer Testosterone
All the authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by BGK, MS, EŞ, OO and IT. The first draft of the manuscript was written by BGK, BO and MKT and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.
No grant received.
Compliance with ethical standards
Conflict of interest
There is no conflict of interest. We confirm that all the authors of this submission have understood and approved the journal’s licensing policy.
Human/animal rights statement
Our research involving human participants.
Our study was approved by the local Ethics Committee regarding Helsinki Declaration and written informed consent was obtained from all participants.
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