Hormonal stimulation of spermatogenesis: a new way to treat the infertile male with non-obstructive azoospermia?

  • Rita J. Laursen
  • Helle O. Elbaek
  • Betina B. Povlsen
  • Jette Lykkegaard
  • Kirsten B. S. Jensen
  • Sandro C. EstevesEmail author
  • Peter Humaidan
Urology - Letter to the editor

Dear Editor,

We herein report a full-term delivery of a healthy child obtained with aid of intracytoplasmic sperm injection (ICSI) in an infertile couple with non-obstructive azoospermia (NOA) and severe endometriosis, following hormonal stimulation of spermatogenesis, cryopreservation of ejaculated spermatozoa using the cell sleeper method, and subsequently ICSI.

Case presentation

A 28-year-old male and his 32-year-old spouse were admitted to The Fertility Clinic Skive due to primary infertility. The couple had tried to conceive for 2 years. The medical history of the male revealed bilateral cryptorchidism and testicles which only fully descended to the scrotum at the age of 12. The reason why the condition was left untreated is unknown. No previous medical treatment or surgery was recorded. The clinical examination of the patient revealed a normal virilized male with both testicles in the scrotum, both having a volume of approximately 8 ml. We noted no abnormalities of the...


Compliance with ethical standards

Conflict of interest


Supplementary material

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Supplementary material 1 (JPG 7963 KB)


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.The Fertility ClinicSkive Regional HospitalSkiveDenmark
  2. 2.Androfert, Andrology and Human Reproduction ClinicReferral Center for Male ReproductionCampinasBrazil
  3. 3.Faculty of HealthAarhus UniversityAarhusDenmark

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