International Urology and Nephrology

, Volume 51, Issue 4, pp 737–743 | Cite as

Ovarian reserve in an Egyptian cohort with end-stage kidney disease on hemodialysis and after successful kidney transplantation: a prospective study

  • Ahmed FayedEmail author
  • Ahmed Soliman
  • Mervat Naguib
  • Mahmoud Soliman
  • M. Salaheldin
Nephrology - Original Paper



Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve.


To assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx).


Sixty women with end-stage kidney disease (ESKD) on regular hemodialysis were included in this study with 20 patients of them were going to have renal transplant. Fifty age-matched healthy females were enrolled as control. Serum AMH level was measured in all participants once and in transplant patients four times (before surgery, and at 1, 6, and 12 months after surgery). AFC was evaluated once in all subjects and in transplant patients twice (before and 1 year after surgery).


ESKD patients had significantly lower AMH concentration and AFC than healthy controls (1.8 ± 1.2 vs. 3.5 ± 1.7 ng/ml, p < 0.001) and (12 ± 4.6 vs. 17.4 ± 4.3, p < 0.001), respectively. In the subgroup transplant patients, AMH level decreased significantly from (1.7 ± 1.3 ng/ml) before Ktx to (1.5 ± 1.2 ng/ml, p = 0.001) at 1 month, (1.1 ± 0.9 ng/ml, p < 0.001) at 6 months, (0.9 ± 0.8 ng/ml, p < 0.001) at 1 year after Ktx. Also, total AFC declined in transplant females from (11.1 ± 4.5) before KTx to (6.6 ± 3.4) after KTx (p < 0.001).


Women with ESKD who are on hemodialysis have lower ovarian reserve than healthy females. Moreover, renal transplantation was associated with reduction in AMH level and AFC.


Antimüllerian hormone Antral follicle count Chronic kidney disease 



This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.

Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.

Ethical approval

The local ethical committee of the Internal Medicine department, School of Medicine, Cairo University, approved this work.

Research involving human and animal participants

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Nephrology Unit, Internal Medicine Department, School of MedicineCairo UniversityCairoEgypt
  2. 2.Endocrinology Unit, Internal Medicine Department, School of MedicineCairo UniversityCairoEgypt
  3. 3.Gynecology and Obstetrics DepartmentCairo University School of Medicine, Cairo UniversityCairoEgypt
  4. 4.Urology DepartmentCairo University School of Medicine, Cairo UniversityCairoEgypt

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