International Urology and Nephrology

, Volume 51, Issue 4, pp 713–721 | Cite as

Functional capacity, renal function and vitamin D in community-dwelling oldest old

  • Lara Miguel Quirino AraujoEmail author
  • Patricia Ferreira do Prado Moreira
  • Clineu de Mello Almada Filho
  • Luciano Vieira de Araujo
  • Michelle Tiveron Passos
  • Gianna Mastroianni Kirsztajn
  • Miguel Cendoroglo Neto
  • Ricardo Castro Cintra Sesso
  • Maysa Seabra Cendoroglo
Nephrology - Original Paper



The aim of this study was to evaluate the association between the decline in estimated glomerular filtration rate (eGFR) and serum 25(OH)D with the physical and mental functional capacity of elderly individuals aged 80 years or older.


We evaluated the functional capacity in its multidomain aspects: Geriatric Depression Scale (GDS), Instrumental Activities of Daily Living (IADL), Mental State Mini-Exam (MMSE), Verbal Fluency Test (VF), handgrip strength and time to sit and rise from a chair five times, combined creatinine and cystatin C-based eGFR and 25(OH)D levels in 205 independent asymptomatic and community-dwelling elderly subjects in a cross-sectional study.


Every 1 year of life, there was reduction of about 10% chance of adequate performance in functional capacity. Each 1 ml/min/m2 in eGFR was associated with 2% better chance of adequate performance in the IADL. We found no association between eGFR and cognition. Serum 25(OH)D between 15.00 and 22.29 ng/ml increased the chance of better performance in VF, IADL, handgrip strength and sit and rise from the chair compared to the lower level of serum vitamin D.


Decreased renal function associated with age compromises the ability to perform activities for independent life in the community, but we did not observe influence in specific domains of cognition and physical performance. Low serum level of 25(OH)D appears to be a marker of greater risk of functional decline than eGFR measurement in independent oldest old dwelling in the community.


Renal function Vitamin D Cognition Physical performance Oldest old 



This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (2011/12753-8).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11255_2019_2081_MOESM1_ESM.docx (40 kb)
Supplementary material 1 (DOCX 40 KB)


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Division of Geriatrics and Gerontology, School of Medicine, Federal University of São PauloUnifespSão PauloBrazil
  2. 2.Information Systems, School of Arts, Sciences and HumanitiesUSPSão PauloBrazil
  3. 3.Division of Nephrology, School of MedicineUnifesp, Federal University of São PauloSão PauloBrazil
  4. 4.Hospital Israelita Albert Einstein, Federal University of São PauloSão PauloBrazil

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