International Urology and Nephrology

, Volume 51, Issue 4, pp 707–712 | Cite as

Increased risk of new-onset type 2 diabetes in people with chronic kidney disease

  • I-Kuan Wang
  • Tsung-Hsun Tsai
  • Yi-Chih Hung
  • Tzu-Yuan Wang
  • Tzung-Hai Yen
  • Cheng-Li Lin
  • Fung-Chang SungEmail author
Nephrology - Original Paper



This study investigated whether people with chronic kidney disease (CKD) are at the risk of new-onset type 2 diabetes.


A cohort comprising 16,624 people with CKD, and an age- and sex-matched control cohort of 66,496 persons without any clinical kidney disease were identified from the Taiwan National Health Insurance Database during the period of 2000–2010. Both cohorts were followed up to 2011 to evaluate the incidence and hazard ratio (HR) of developing new-onset type 2 diabetes. Diseases were identified based on diagnosis coding.


The incidence of type 2 diabetes was 1.51-fold higher in the CKD cohort than in the control cohort (16.9 versus 11.2 per 1,000 person-years) with an adjusted hazard ratio of 1.17 (95% confidence interval, (CI)1.10–1.24). In the multivariate Cox regression model considering the competing-risk death, the adjusted subhazard ratio of type 2 diabetes was 1.30 (95% CI1.22–1.38) for the CKD cohort compared to the control cohort.


People with CKD patients are at an increased risk of developing new-onset type 2 diabetes. Close surveillance for diabetes should be considered for these people.


Diabetes Incidence Insulin resistance Chronic kidney disease 



This study is supported in part by Grants from the Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004), Children’s Hospital of China Medical University (DMR-105-041), China Medical University Hospital (DMR-107-026, DMR-107-176, and DMR-108-111), Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10601010036), Taiwan Clinical Trial Consortium for Stroke (MOST 107-2321-B-039-004), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • I-Kuan Wang
    • 1
    • 2
  • Tsung-Hsun Tsai
    • 3
    • 4
  • Yi-Chih Hung
    • 5
  • Tzu-Yuan Wang
    • 5
  • Tzung-Hai Yen
    • 6
    • 7
  • Cheng-Li Lin
    • 6
  • Fung-Chang Sung
    • 3
    • 8
    • 9
    Email author
  1. 1.Department of Internal Medicine, College of MedicineChina Medical UniversityTaichungTaiwan
  2. 2.Division of NephrologyChina Medical University HospitalTaichungTaiwan
  3. 3.Graduate Institute of Clinical Medical ScienceChina Medical University College of MedicineTaichungTaiwan
  4. 4.Division of Urology, Department of SurgeryTaichung Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationTaichungTaiwan
  5. 5.Division of EndocrinologyChina Medical University HospitalTaichungTaiwan
  6. 6.Division of NephrologyChang Gung Memorial HospitalTaipeiTaiwan
  7. 7.Chang Gung University College of MedicineTaoyuanTaiwan
  8. 8.Management Office for Health DataChina Medical University HospitalTaichungTaiwan
  9. 9.Department of Health Services AdministrationChina Medical UniversityTaichungTaiwan

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