Current epidemiology and practice patterns in prevention and treatment of PD-related infections in Poland
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Peritoneal dialysis (PD) related infections are associated with technique failure and mortality. The aim of this multicentre study was to examine epidemiology, treatment and outcomes of PD-related infections in Poland as well as practice patterns for prevention of these complications in the context of current ISPD recommendations.
A survey on PD practices in relation to infectious complications was conducted in 11 large Polish PD centres. Epidemiology of peritonitis and exit-site infections (ESI) was examined in all patients treated in these units over a 2 year period.
The study included data on 559 PD patients with 62.4% on CAPD. Practice patterns for prevention of infectious complications are presented. The rate of peritonitis was 0.29 episodes per year at risk, with Gram positive microorganisms responsible for more than 50% of infections and 85.8% effectively treated. Diagnosis and treatment followed ISPD guidelines however most units did not provide an anti-fungal prophylaxis. Although neither of the centres reported routine topical mupirocin on catheter exit-site, the rate of ESI was low (0.1 episodes per year at risk), with Staphylococcus aureus as most common pathogen and full recovery in 78.3% of cases.
The study shows rewarding outcomes in prevention and treatment of PD-associated infections, mainly due to a thorough compliance with the current ISPD guidelines, although some deviations from the recommendations in terms of practice patterns have been observed. More studies are needed in large numbers of patients to differentiate the importance of specific recommendations and further support the guidelines.
KeywordsPeritoneal dialysis Infection Peritonitis
There was no funding to the study.
Compliance with ethical standards
Conflict of interest
MLN,JMR,EG,BS,MG,PJ - Speaker’s honoraria from Fresenius Medical Care, MLN,MC,BN,EG,BS,EW,ES,MG,RK- Speaker’s honoraria from Baxter, BN,BS - Speaker’s honoraria from MSD, BN - Speaker’s honoraria from Amgen, JMR, BN,BS - Speaker’s honoraria from Roche, BS - Speaker’s honoraria from Servier, MLN,BN,JMR,EG,ES,BS,MG - Travel sponsorship from Fresenius Medical Care, BS - Travel sponsorship from Servier, MLN, PJ, BM, MA,KK,RK,KC - employees of Fresenius Nephrocare Dialysis Units, MB declares that he has no conflict of interest
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study contains retrospective observational data. For this type of study formal consent is not required. Protocol of the study received approval from the Local Bioethics Committee.
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