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Evaluating the associations between urinary excretion of magnesium and that of other components in calcium stone-forming patients

  • Sanaz Tavasoli
  • Maryam Taheri
  • Fatemeh Taheri
  • Abbas Basiri
  • Fahimeh Bagheri Amiri
Nephrology - Original Paper
  • 4 Downloads

Abstract

Purpose

Magnesium plays numerous vital roles in human’s body. It is known as a protective factor in stone formation by binding to oxalate in the intestinal and urinary system, and decreasing its absorption and crystallization, respectively. Due to controversies about the association between the 24-h urine magnesium and other urine metabolites in different studies, this study was designed to find a clear answer to this question.

Methods

In this retrospective cross-sectional study, data from 24-h urinalysis of the calcium stone-forming (CSF) patients were assessed. The correlation between 24-h urine (24-U) magnesium to creatinine ratio (Mg/Cr) with other 24-U metabolites to creatinine ratio was assessed, using Spearman correlation test. The association between 24-U magnesium and 24-U oxalate was also studied in a multivariate logistic regression model.

Results

Among 965 patients, the level of Mg/Cr showed a direct association with all other 24-U metabolite to Cr ratio (p-value < 0.001 for all analyses). The result of multivariate regression analysis showed that the higher quartile of 24-U oxalate (> 47 mg/24 h) increased the odds of 24-U magnesium more than 75 mg/24 h (data median) (OR 1.89, 95% CI 1.14–3.13) comparing with the lower quartile of 24-U oxalate (≤ 26 mg/24 h).

Conclusions

In a routine dietary habit, since rich sources of magnesium contain a high amount of oxalate at the same time, it is not surprising that magnesium level in 24-h urinalysis showed a direct association with 24-h urine oxalate.

Keywords

Association Calcium stones Magnesium Oxalate Urine metabolites 

Notes

Acknowledgements

We thank our colleagues from Shahid Labbafinejad Medical Center for their kind cooperation in our study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Urology Nephrology Research Center institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study formal consent is not required.

References

  1. 1.
    Maguire ME, Cowan JA (2002) Magnesium chemistry and biochemistry. Biometals 15:203–210CrossRefGoogle Scholar
  2. 2.
    Cowan J (2002) Structural and catalytic chemistry of magnesium-dependent enzymes. Biometals 15:225–235CrossRefGoogle Scholar
  3. 3.
    Shils ME, Shike M (2006) Modern nutrition in health and disease. Lippincott Williams & Wilkins, BaltimoreGoogle Scholar
  4. 4.
    Levy FL, Adams-Huet B, Pak CY (1995) Ambulatory evaluation of nephrolithiasis: an update of a 1980 protocol. Am J Med 98:50–59CrossRefGoogle Scholar
  5. 5.
    Schwartz BF, Bruce J, Leslie S, Stoller ML (2001) Rethinking the role of urinary magnesium in calcium urolithiasis. J Endourol 15:233–235.  https://doi.org/10.1089/089277901750161638 CrossRefPubMedGoogle Scholar
  6. 6.
    Massey L (2005) Magnesium therapy for nephrolithiasis. Magnes Res 18:123–126PubMedGoogle Scholar
  7. 7.
    Preminger G, Baker S, Peterson R, Poindexter J, Pak C (1989) Hypomagnesiuric hypocitraturia: an apparent new entity for calcium nephrolithiasis. J Lithotr Stone Dis 1:22–25Google Scholar
  8. 8.
    Eisner BH, Sheth S, Dretler SP, Herrick B, Pais VM Jr (2012) High dietary magnesium intake decreases hyperoxaluria in patients with nephrolithiasis. Urology 80:780–783.  https://doi.org/10.1016/j.urology.2012.06.033 CrossRefPubMedGoogle Scholar
  9. 9.
    Nakada SY, Hoff DG, Attai S, Heisey D, Blankenbaker D, Pozniak M (2000) Determination of stone composition by noncontrast spiral computed tomography in the clinical setting. Urology 55:816–819CrossRefGoogle Scholar
  10. 10.
    Türk C, Neisius A, Petrik A, Seitz C, Skolarikos A, Thomas K (2017) EAU guidelines on urolithiasis european association of urology. http://uroweb.org/guideline/urolithiasis/
  11. 11.
    Tiselius HG (1991) Aspects on estimation of the risk of calcium oxalate crystallization in urine. Urol Int 47:255–259CrossRefGoogle Scholar
  12. 12.
    Tiselius HG (1997) Risk formulas in calcium oxalate urolithiasis. World J Urol 15:176–185CrossRefGoogle Scholar
  13. 13.
    Marangella M, Petrarulo M, Daniele PG, Sammartano S (2002) LithoRisk: a software for calculating and visualising nephrolithiasis risk profiles. G Ital Nefrol 19:693–698PubMedGoogle Scholar
  14. 14.
    Bultitude MF (2012) Campbell-Walsh urology tenth edition. Elsevier, PhiladelphiaCrossRefGoogle Scholar
  15. 15.
    Türk C, Knoll T, Petrik A, Sarica K, Straub M, Seitz C (2012) EAU guiedline in urolithiasis. European Association of Urology. https://uroweb.org/wp-content/uploads/20_Urolithiasis_LR-March-13-2012.pdf
  16. 16.
    Favus MJ, Goltzman G (2008) Regulation of calcium and magnesium. In: Rosen CJ, Bouillon R, Compston JE, Rosen V (eds) Primer on the metabolic bone diseases and disorders of mineral metabolism. Wiley, New York, pp 104–108Google Scholar
  17. 17.
    Siener R, Ebert D, Nicolay C, Hesse A (2003) Dietary risk factors for hyperoxaluria in calcium oxalate stone formers. Kidney Int 63:1037–1043.  https://doi.org/10.1046/j.1523-1755.2003.00807.x CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehranIran
  2. 2.School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran

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