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International Urology and Nephrology

, Volume 51, Issue 1, pp 175–180 | Cite as

Prevalence of pulmonary hypertension in peritoneal dialysis patients: a meta-analysis

  • Yuanyuan Li
  • Weifeng Shang
  • Qiaofa Lu
  • Bo Zhang
  • Yali Ren
  • Yanbo SunEmail author
  • Junwu DongEmail author
Nephrology - Original Paper

Abstract

Purpose

Recent epidemiological evidence indicates an association between peritoneal dialysis (PD) patients and pulmonary hypertension (PH). However, the true prevalence of PH associated with PD has not been well described. So we conducted a meta-analysis to summarize the point prevalence of PH in adults with PD.

Methods

PubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies. We used a random-effect meta-analysis model to estimate the prevalence of PH. We also performed sensitivity analyses and assessments of publishing bias.

Results

Fourteen observational studies (n = 1483 participants) were included in this meta-analysis. The result of analysis in random-effect model showed that the pooled prevalence was 21% (95% CI 16–28), with significant heterogeneity between these studies (I2 = 84%, p < 0.01). Sensitivity analysis further demonstrated the results to be robust. Besides, the Egger’s test (p = 0.287) showed no significant publication bias.

Conclusions

PH is highly prevalent in patients with PD. Further studies are encouraged to definitively clarify the relationship between PH and PD.

Keywords

Pulmonary hypertension Prevalence Peritoneal dialysis Meta-analysis 

Abbreviations

CKD

Chronic kidney disease

PD

Peritoneal dialysis

PH

Pulmonary hypertension

PASP

Pulmonary artery systolic pressure

Notes

Author contributions

JD and WS conceived and designed the study. YL, WS, BZ, and YR screened the abstract and full text, extracted data, assessed studies and drafted the manuscript. YL, WS, QL, and YS performed statistical analyses. YL, WS, and JD revised the manuscript. All authors read the manuscript and approved the final version.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Research involving human and animal participants

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

11255_2018_2017_MOESM1_ESM.docx (193 kb)
Supplementary material 1 (DOCX 192 KB)

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Respiratory Medicine, Wuhan Forth Hospital; Puai Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  2. 2.Department of Nephrology and Rheumatology, Wuhan Forth Hospital; Puai Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  3. 3.Department of Medical Affaires, Liyuan Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  4. 4.Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China

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