Prevalence of pulmonary hypertension in peritoneal dialysis patients: a meta-analysis
Recent epidemiological evidence indicates an association between peritoneal dialysis (PD) patients and pulmonary hypertension (PH). However, the true prevalence of PH associated with PD has not been well described. So we conducted a meta-analysis to summarize the point prevalence of PH in adults with PD.
PubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies. We used a random-effect meta-analysis model to estimate the prevalence of PH. We also performed sensitivity analyses and assessments of publishing bias.
Fourteen observational studies (n = 1483 participants) were included in this meta-analysis. The result of analysis in random-effect model showed that the pooled prevalence was 21% (95% CI 16–28), with significant heterogeneity between these studies (I2 = 84%, p < 0.01). Sensitivity analysis further demonstrated the results to be robust. Besides, the Egger’s test (p = 0.287) showed no significant publication bias.
PH is highly prevalent in patients with PD. Further studies are encouraged to definitively clarify the relationship between PH and PD.
KeywordsPulmonary hypertension Prevalence Peritoneal dialysis Meta-analysis
Chronic kidney disease
Pulmonary artery systolic pressure
JD and WS conceived and designed the study. YL, WS, BZ, and YR screened the abstract and full text, extracted data, assessed studies and drafted the manuscript. YL, WS, QL, and YS performed statistical analyses. YL, WS, and JD revised the manuscript. All authors read the manuscript and approved the final version.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
Research involving human and animal participants
This article does not contain any studies with human participants or animals performed by any of the authors.
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