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Tropical Animal Health and Production

, Volume 51, Issue 7, pp 2011–2018 | Cite as

Factors associated with persistence of African animal trypanosomiasis in Lango subregion, northern Uganda

  • Robert Mandela Wangoola
  • Bardosh Kevin
  • Christine Among Acup
  • Susan Welburn
  • Charles Waiswa
  • James BugezaEmail author
Regular Articles

Abstract

African animal trypanosomiasis (AAT) continues to inflict heavy losses on livestock production especially cattle in terms of decreased production and productivity in Uganda. AAT is a disease complex caused by tsetse fly-transmitted Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma congolense, and Trypanosoma vivax. The disease is most important in cattle but also known to cause serious losses in pigs, camels, goats, and sheep. Several control measures including live bait technology, mass treatment of cattle with trypanocidal drugs, and deployment of tsetse traps have been used in the past 10 years, but the problem still persists in some areas. This necessitated an exploration of the factors associated with continued trypanosome infections in cattle, which are also known reservoirs for the zoonotic trypanosomiasis. A structured questionnaire was administered to 286 animal owners from 20 villages purposively selected from Lira, Kole, and Alebtong districts of Lango subregion to obtain information on the factors associated with persistence of infection. Over 50% of the respondents reported trypanosomiasis as a major challenge to their livestock. Land ownership (P = 0.029), type of livestock kept (P = 0.000), disease control strategy employed (P = 0.000), source of drugs (P = 0.046), and drug preparation (P = 0.017) were associated with persistent AAT infection. We recommend continued farmer sensitization on the threat of AAT and the available prevention and control options. The use of isometamidium chloride for prophylaxis against trypanosomiasis is highly recommended. There is also a need to foster qualified private veterinary drug supply in the region.

Keywords

African animal trypanosomiasis Uganda Lango sub region Isometamidium chloride Trypanosomes 

Abbreviations

AAT

African animal trypanosomiasis

COCTU

Coordinating Office for the Control of Trypanosomiasis in Uganda

TIBA

Tackling Infections to Benefit Africa

UBOS

Uganda Bureau of Statistics, T.vivax, Trypanosoma vivax; T.congolense, Trypanosoma congolense

Notes

Acknowledgments

We wish to acknowledge the contribution made by the following towards this study, the Tackling Infections to Benefit Africa (TIBA), the National Institute for Health Research (NIHR) Coordinating Office for Control of Trypanosomiasis in Uganda (COCTU), and the Uganda Trypanosomiasis Control Council (UTCC).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of animal rights

All applicable guidelines for the care and use of animals were followed.

References

  1. Bardosh, K., Waiswa, C., & Welburn, S. C. (2013). Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda. Parasites & vectors, 6(1), 204.CrossRefGoogle Scholar
  2. Bugeza, J., Kankya, C., Muleme, J., Akandinda, A., Sserugga, J., Nantima, N., Okori, E., & Odoch, T. (2017). Participatory evaluation of delivery of animal health care services by community animal health workers in Karamoja region of Uganda. PloS one, 12(6), e0179110.CrossRefGoogle Scholar
  3. Byarugaba, D. (2004). Antimicrobial resistance in developing countries and responsible risk factors. International journal of antimicrobial agents, 24(2), 105–110.CrossRefGoogle Scholar
  4. Byarugaba, D. K., Kisame, R., & Olet, S. (2011). Multi-drug resistance in commensal bacteria of food of animal origin in Uganda. African Journal of Microbiology Research, 5(12), 1539–1548.CrossRefGoogle Scholar
  5. Fèvre, E., Coleman, P., Odiit, M., Magona, J., Welburn, S., & Woolhouse, M. (2001). The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda. The Lancet, 358(9282), 625–628.CrossRefGoogle Scholar
  6. Fussgänger, R., & Bauer, F. (1958). Berenil: ein neues chemotherapeuticum in der veterinärmedizin. Medizin und chemie, 6, 504–531.Google Scholar
  7. Ilukor, J., Birner, R., Rwamigisa, P., & Nantima, N. (2013). Analysis of veterinary service delivery in Uganda: an application of the Process Net-Map Tool. Hohenheim and Kampala: University of Hohenheim, Institute of Agricultural Economics and Social Sciences in the Tropics and Subtropics, Germany, and Ministry of Agriculture Animal Industry and Fisheries Department of Livestock Health and Entomology.Google Scholar
  8. Joloba, M., Bajaksouzian, S., Palavecino, E., Whalen, C., & Jacobs, M. (2001). High prevalence of carriage of antibiotic-resistant Streptococcus pneumoniae in children in Kampala Uganda. International journal of antimicrobial agents, 17(5), 395–400.CrossRefGoogle Scholar
  9. Mbowa, S., Shinyekwa, I., & Lwanga, M. (2012). The challenges of the private sector driven veterinary extension services delivery in the dairy sector in Uganda.Google Scholar
  10. Miller, L. D. (2017). Farming practices and Trypanosomiasis in Northern Uganda: an assessment of Trypanosomiasis prevalence and the ongoing management of vector borne infections.Google Scholar
  11. Moloo, S., Kutuza, S., & Desai, J. (1987). Comparative study on the infection rates of different Glossina species for East and West African Trypanosoma vivax stocks. Parasitology, 95(3), 537–542.CrossRefGoogle Scholar
  12. Mukiibi, H., Waiswa, C., Waiswa, P., Matovu, E., Kabasa, J. D., Olet, S., & Khaitsa, M. L. (2017). Evaluation of a “Stamp Out Sleeping Sickness” campaign in Uganda to control human African trypanosomiasis (2004–2009). Pan African Medical Journal(ARTISSUE).Google Scholar
  13. Picozzi, K., Fèvre, E., Odiit, M., Carrington, M., Eisler, M. C., Maudlin, I., & Welburn, S. C. (2005). Sleeping sickness in Uganda: a thin line between two fatal diseases. Bmj, 331(7527), 1238–1241.CrossRefGoogle Scholar
  14. Rutto, J. J., Osano, O., Thuranira, E. G., Kurgat, R. K., & Odenyo, V. A. O. (2013). Socio-economic and cultural determinants of human African trypanosomiasis at the Kenya–Uganda transboundary. PLoS neglected tropical diseases, 7(4), e2186.CrossRefGoogle Scholar
  15. Selby, R., Bardosh, K., Picozzi, K., Waiswa, C., & Welburn, S. C. (2013). Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post-conflict Uganda. Parasites & vectors, 6(1), 281.CrossRefGoogle Scholar
  16. Tobler, M., Cochard, R., & Edwards, P. (2003). The impact of cattle ranching on large-scale vegetation patterns in a coastal savanna in Tanzania. Journal of Applied Ecology, 40(3), 430–444.CrossRefGoogle Scholar
  17. Trail, J. C. (1985). Productivity of Boran cattle maintained by chemoprophylaxis under trypanosomiasis risk (Vol. 9): ILRI (aka ILCA and ILRAD).Google Scholar
  18. Von Wissmann, B., Machila, N., Picozzi, K., Fèvre, E. M., Barend, M., Handel, I. G., & Welburn, S. C. (2011). Factors associated with acquisition of human infective and animal infective trypanosome infections in domestic livestock in western Kenya. PLoS neglected tropical diseases, 5(1), e941.CrossRefGoogle Scholar
  19. Wacher, T., Milligan, P., Rawlings, P., & Snow, W. (1994). Tsetse–trypanosomiasis challenge to village N'Dama cattle in The Gambia: field assessments of spatial and temporal patterns of tsetse–cattle contact and the risk of trypanosomiasis infection. Parasitology, 109(2), 149–162.CrossRefGoogle Scholar
  20. Waiswa, C., & Kabasa, J. D. (2010). Experiences with an in-training community service model in the control of zoonotic sleeping sickness in Uganda. Journal of veterinary medical education, 37(3), 276–281.CrossRefGoogle Scholar
  21. Welburn, S., Picozzi, K., Fèvre, E. M., Coleman, P., Odiit, M., Carrington, M., & Maudlin, I. (2001). Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene. The Lancet, 358(9298), 2017–2019.CrossRefGoogle Scholar
  22. Zhang, Z., Giroud, C., & Baltz, T. (1991). In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium. Acta tropica, 50(2), 101–110.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Coordinating Office for Control of Trypanosomiasis in UgandaKampalaUganda
  2. 2.University of FloridaGainesvilleUSA
  3. 3.Edinburgh Medical School: Biomedical SciencesUniversity of EdinburghEdinburghUK
  4. 4.National Livestock Resources Research Institute (NaLIRRI)WakisoUganda

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