The effects of PPR on the reproductive health of Black Bengal goats and the possible role played by oxidative stress

  • Pankaj Kumar
  • Amitava Dey
  • Abhay Kumar
  • Pradeep Kumar Ray
  • Poolangulam Chinnakkan Chandran
  • Rashmi Rekha Kumari
  • Manish Kumar
Regular Articles
Part of the following topical collections:
  1. The Gordon Scott Collection

Abstract

Outbreaks of Peste des petits ruminants (PPR) viral disease in Black Bengal goats were investigated from the middle Indo-Gangetic Plains of India. Clinical profile of PPR-affected flocks was recorded from four different outbreak sites of the region. The PPR outbreak was diagnosed serologically using commercially available sandwich ELISA kit. Relatively, low mortality rate (mean 26.75%) for PPR outbreak was recorded due to the endemic status of the disease. To understand the role of oxidative stress in PPR virus pathogenesis, various oxidant and antioxidant parameters in goats infected with PPR were estimated and compared with the uninfected/healthy goats of the same flock. The measured high level of pro-oxidant malondialdehyde (MDA) obtained from lipid peroxidation along with lower levels of anti-oxidants viz. superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in PPR-affected Black Bengal goats suggests oxidative stress as one of the mechanism of pathogenesis of PPR virus. In addition, the correlation of oxidative stress due to PPR and the resulting reproductive disorders in the female goats were evaluated. The abortion in pregnant does observed during PPR outbreak was proportional to debility and oxidative stress manifested during PPR infection. The reproductive performance of recovered female goats in the period of 18 months of monitoring was significantly compromised in terms of kidding and twinning frequency. The mortality rate in kids born from PPR-recovered goats was significantly higher compared to those from health goats in the first 9 months post-recovery. From the present study, it may be concluded that together with the PPR virus, infection in goats and the resulting oxidative stress play a vital role for abortion and reduced post-reproductive performance in Black Bengal female goat.

Keywords

Goat Black Bengal PPR Oxidative stress Reproduction 

Notes

Acknowledgements

The support provided by the Programme Coordinators of the Krishi Vigyan Kendras, Principal, Bihar Veterinary College, and the NAIP component-3 project field staff during survey, sampling and data recording is duly acknowledged. The authors are also thankful to the Station in Charge of IVRI Mukteshwar for providing ELISA kits.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Abubakar, M., Ali, Q. and Khan, H. A., 2008. Prevalence and mortality rate of peste des petitis ruminant (PPR): possible association with abortion in goat, Tropical Animal Health and Production, 40, 317–321.CrossRefPubMedGoogle Scholar
  2. Balamurugan, V., Rahman, H. and Munir, M., 2015. Host Susceptibility to Peste des Petits Ruminants Virus. In: Munir M. (eds) Peste des Petits Ruminants Virus. Springer, Berlin, Heidelberg, 39–50.Google Scholar
  3. Chauhan, H.C., Kher, H.N., Rajak, K.K., Sen, A., Dadawala, A.I. and Chandel, B.S., 2014. Epidemiology and diagnosis of peste des petits ruminants in sheep and goats by serological, molecular and isolation methods in Gujarat, India, Advances in Animal and Veterinary Sciences, 2, 192–198.CrossRefGoogle Scholar
  4. Chowdhury, E. H., Bhuiyan, A. R., Rahman, M. M., Siddique, M. S. A. and Islam, M. R. 2014. Natural PPR virus infection in Black Bengal goat: Virological, Pathological and Immunohistochemical investigations, BMC Veterinary Research, 10, 263–273.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Goth, L., 1991. A simple method for determination of serum catalase activity and revision of reference range, Clinica Chimica Acta, 196, 143–152.CrossRefGoogle Scholar
  6. Haldar, A., Pal, P., Datta, M., Paul, R., Pal, S. K., Majumdar, D., Biswas, C. K. and Pan, S., 2014. Prolificacy and its relationship with age, body weight, parity, previous litter size and body linear type traits in meat-type goats, Asian-Australasian Journal of Animal Sciences, 27, 628–634.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Jagtap, S.P., Rajak, K.K., Garg, U.K., Bhanuprakash, V., Sudhakar, S.B., Balamurugan, V., Anuj, P., Ahuja, A., Singh, R.K. and Vanamayya, P.R., 2012. Effect of immunosuppression on the pathogenesis of Peste des Petits Ruminants virus infection in goats, Microbial Pathogenesis, 52, 217–226.CrossRefPubMedGoogle Scholar
  8. Kardjadj, M., Metref, D., Pam, D.L., Ben-Mahdi, M. H., 2016. Abortion and various associated risk factors in Algerian small ruminants flocks. Preventive Veterinary Medicine. 123: 97–101.CrossRefPubMedGoogle Scholar
  9. Karim, A., Bhattacharjee, U., Puro, K., Shakuntala, I., Sanjukta, R., Das, S., Gahata, S. and Sen, A., 2016. Detection of Peste des petits ruminants virus and goat pox virus from an outbreak in goats with high mortality in Meghalaya state, India, Veterinary World, 9(9), 1025–1027.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Kataria, A. K. and Kataria, N., 2013. Assessment of oxidative stress in Peste des petits ruminants (Ovine rinderpest) affected goats, Media Peternakan, 35, 170–174.CrossRefGoogle Scholar
  11. Kumar, N., Chaubeya, K. K., Chaudharya, K., Singh, S. V., Sharma, D. K., Gupta, V. K., Mishra, A. K. and Sharma, S., 2013. Isolation, identification and characterization of a Peste des Petits Ruminants virus from an outbreak in Nanakpur, India. Journal of Virological Methods, 189, 388–392.CrossRefPubMedGoogle Scholar
  12. Kumar, P., Sinha, B. S., Roy, R. K., Kumari, R. R. and Kumar, A., 2017. Peste des petits ruminants in goats: Sero-epidemiological study in middle Indo-Gangetic plains, Indian Journal of Animal Sciences, 87, 418–421.Google Scholar
  13. Landis, J. R. and Koch, G. G., 1977. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers, Biometrics, 33, 363–374.CrossRefPubMedGoogle Scholar
  14. Lawrence, R. A. and Burk, R. F., 1976. Glutathione peroxidase activity in selenium-deficient rat liver, Biochemical and Biophysical Research Communication, 71, 952–958.CrossRefGoogle Scholar
  15. Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P. and Malik, A. B., 2014. Reactive oxygen species in inflammation and tissue injury, Antioxidants and Redox Signalling, 20, 1126–1167.CrossRefGoogle Scholar
  16. Muthuchelvan, D., Rajak, K.K., Ramakrishnan, M.M., Choudhary, D., Bhadouriya, S., Saravanan, P., Pandey, A.B. and Singh, R.K., 2015. Peste-des-petits-ruminants:An Indian perspective. Advances in Animal and Veterinary Sciences, 3, 422–429.CrossRefGoogle Scholar
  17. Placer, A. Z., Linda, L. C. and Johnson, B., 1966. Estimation of product of lipid peroxidation (Malonly Dialdehyde) in biochemical systems, Analytical Biochemistry, 16, 359–364.CrossRefPubMedGoogle Scholar
  18. Pohanka, M., 2013. Role of oxidative stress in infectious diseases. A review, Folia Microbiologica, 58, 503–513.CrossRefPubMedGoogle Scholar
  19. Ray, S., Dash, S.K., Dhal, S.K., Nayak, G.D. and Parida, A.K., 2016. Genetic studies on reproductive performance of indigenous goats in northern Odisha, Exploratory Animal and Medical Research, 6, 192–198Google Scholar
  20. Santhamani, R., Singh, R.P. and Njeumi, F., 2016. Peste des petits ruminants diagnosis and diagnostic tools at a glance: perspectives on global control and eradication, Archives of Virology, 161, 2953–2967.CrossRefPubMedGoogle Scholar
  21. Singh, B., Bardhan, D., Verma, M. R., Prasad, S. and Sinha, D. K., 2014. Estimation of economic losses due to Peste de Petits Ruminants in small ruminants in India, Veterinary World, 7, 194--199.CrossRefGoogle Scholar
  22. Sun, Y., Larry, W., Oberley, W. and Ying, L., 1988. A simple method for clinical assay of superoxide dismutase. Clinical Chemistry, 24, 497–500.Google Scholar
  23. Tekeli, H., Kıral, F., Bildik, A., Yılmaz, M.and Kaçamaklı, Z., 2015. Effect of aging on enzymatic and non-enzymatic antioxidant status in Saanen goats. Veterinarija ir Zootechnika, 71, 67–71.Google Scholar
  24. Zahur, A.B., Ullah, A., Irshad, H, Latif, A., Ullah, R.W., Jahangir, M., Afzal, M., Khan, S.A. and Salaria, S.M., 2014, Epidemiological analysis of Peste des Petits Ruminants (PPR) outbreaks in Pakistan, Journal of Biosciences and Medicines, 2, 18–26.CrossRefGoogle Scholar
  25. Zhang, Y., Wang, Z., Chen, H., Chen, Z. and Tian, Y., 2014. Antioxidants: potential antiviral agents for Japanese encephalitis virus infection, International Journal of Infectious Diseases, 24, 30–36.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.ICAR Research Complex for Eastern RegionPatnaIndia
  2. 2.Division of Livestock and Fisheries ManagementICAR Research Complex for Eastern RegionPatnaIndia
  3. 3.Bihar Veterinary CollegePatnaIndia
  4. 4.Department of Biosciences and BioengineeringIIT GuwahatiGuwahatiIndia

Personalised recommendations