Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population
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Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.
KeywordsDeep vein thrombosis MicroRNA Single nucleotide polymorphism Pulmonary embolism
This study was partially supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, South Korea (HI16C1559 & HI18C19990200) and partially supported by National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2016R1D1A1B03930141 & NRF-2017R1D1A1B03029582).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All study protocols of participants were reviewed and approved by The Institutional Review Board of CHA Bundang Medical Center and followed the recommendations of the Declaration of Helsinki.
Written informed consent was obtained from all the participants.
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