Journal of Thrombosis and Thrombolysis

, Volume 46, Issue 4, pp 549–550 | Cite as

Pacemaker-associated thrombosis in ongoing therapy with edoxaban tosylate

  • Angelo Di VincenzoEmail author
  • Alessandro Rizzo
  • Lucia Russo
  • Roberto Mioni


Thromboembolism is a known complication of pacemaker implantation. However, published literature describes only a few cases, in which the events occurred in absence of antithrombotic prophylaxis, not routinely employed for its prevention in current clinical practice. We report a case of pacemaker lead-associated thrombosis in a patient taking continuative oral anticoagulant therapy with edoxaban tosylate (edoxaban). No data in present literature supports the use of anticoagulant prophylaxis for pacemaker lead thrombosis. In our report ongoing treatment with edoxaban proved ineffective for thrombosis prevention. We also discuss the role of three-dimensional transthoracic echocardiography for diagnostic assessment of thrombosis in a fragile patient.


Pacemaker Thrombosis Anticoagulation Edoxaban 

Supplementary material

11239_2018_1733_MOESM1_ESM.avi (55.6 mb)
Online resource 1. Electrocatheter thrombosis. (AVI 56903 KB)
11239_2018_1733_MOESM2_ESM.avi (61.7 mb)
Online resource 2. Thrombus prolapsing in the right ventricle (AVI 63225 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Angelo Di Vincenzo
    • 1
    Email author
  • Alessandro Rizzo
    • 2
  • Lucia Russo
    • 1
  • Roberto Mioni
    • 1
  1. 1.Internal Medicine 3University Hospital of PadovaPaduaItaly
  2. 2.Cardiology ClinicUniversity Hospital of PadovaPaduaItaly

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