Journal of Thrombosis and Thrombolysis

, Volume 47, Issue 1, pp 1–7 | Cite as

Anticoagulation and stress-induced cardiomyopathy

  • Saagar K. SanghviEmail author
  • David M. Harris


Stress-induced cardiomyopathy (SCM), is a reversible cardiomyopathy characterized by transient systolic dysfunction following an acute physiologic stress. Thromboembolism occurs at a high frequency in patients with intracardiac thrombus secondary to SCM, with one systematic review reporting a rate of 33.3%. The risk of thrombus formation following SCM has been associated with left-ventricular (LV) contraction abnormalities, catecholaminergic surge, and other associated comorbidities. However, established guidelines for screening and management of intracardiac thrombus in the setting of SCM do not exist at present due to a lack of sufficient clinical trial data. The purpose of this article is to discuss the pathophysiological theory and previously documented evidence from cases of LV thrombus secondary to SCM, and to present our recommendations for management of intracardiac thrombus secondary to SCM.


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Conflict of interest

The authors of this paper have no conflicts of interest.

Ethical approval

Methods and practices for literature review conducted for this paper were in compliance with ethical standards maintained by the University of Cincinnati and the Journal of Thrombosis and Thrombolysis.

Informed consent

No informed consent was required as this was a literature review of existing published journal articles and not a research study.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Division of Cardiovascular Health and Disease, Department of Internal MedicineUniversity of Cincinnati College of MedicineCincinnatiUSA

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