The strange case of achiral compounds which were reported to always crystallize in the same chiral group

  • Ibon AlkortaEmail author
  • José Elguero
Review Article


In the present review, one of the mysteries of chemistry, the non-stochastic preference for one enantiomer during crystallization processes, is discussed with some examples of the literature and one published by our own group.


Cryptochirality Bayesian model Scalemic Absolute asymmetric synthesis Viedma ripening 



Computer, storage, and other resources from the CTI (CSIC) are gratefully acknowledged. This publication is dedicated to Professor Meir Lahav for his seminal contributions to this field.

Funding information

This work was carried out with financial support from the Ministerio de Economía y Competitividad (Project Nos. CTQ2015-63997-C2-2-P) and Comunidad Autónoma de Madrid (Project Fotocarbon, ref. S2013/MIT-2841).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (CSIC)MadridSpain

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