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Russian Chemical Bulletin

, Volume 68, Issue 8, pp 1621–1628 | Cite as

Synthesis and pharmacological activity of a silicon—zinc—boron-containing glycerohydrogel

  • T. G. KhoninaEmail author
  • O. N. Chupakhin
  • N. V. Kungurov
  • N. V. Zilberberg
  • N. P. Evstigneeva
  • M. M. Kokhan
  • A. I. Polishchuk
  • V. V. Permikin
  • E. V. Shadrina
  • E. Yu. Nikitin
  • L. P. Larionov
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Abstract

A new pharmacologically active nanostructured silicon—zinc—boron-containing glycerohydrogel was synthesized by the sol—gel method using silicon, zinc, and boron glycerolates as biocompatible precursors. The hydrogel composition and structural features were investigated by transmission electron microscopy, powder X-ray diffraction, IR spectroscopy, atomic emission spectrometry, and elemental analysis; a structural model was proposed. It was found that the 3D framework of the gel is formed by the products of hydrolysis and subsequent (co)condensation of silicon- and boron-containing precursors. Meanwhile, the major part of zinc monoglycerolate does not undergo hydrolytic transformations during gelation, being present in the 3D framework cells as amorphous nano-sized particles. The dispersion medium of the gel is an aqueous glycerol solution of silicon and boron glycerolates, products of their hydrolytic transformations, and water-soluble products of hydrolytic transformations of zinc monoglycerolate. The silicon—zinc—boron gel is nontoxic and possesses wound-healing and antimicrobial activities; it can be considered as a nanostructured dispersed system promising for biomedical applications, which is prepared in a simple and cost-effective way without using catalysts or toxic organic solvents.

Key words

silicon glycerolates zinc monoglycerolates boron bis-glycerolates biocompatible precursors sol—gel synthesis silicon—zinc—boron glycerohydrogel nanostructured dispersion system wound-healing and antimicrobial activities 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • T. G. Khonina
    • 1
    • 2
    Email author
  • O. N. Chupakhin
    • 1
    • 3
  • N. V. Kungurov
    • 4
  • N. V. Zilberberg
    • 4
  • N. P. Evstigneeva
    • 4
  • M. M. Kokhan
    • 4
  • A. I. Polishchuk
    • 4
  • V. V. Permikin
    • 1
  • E. V. Shadrina
    • 1
  • E. Yu. Nikitin
    • 1
  • L. P. Larionov
    • 5
  1. 1.Ural Branch of the Russian Academy of SciencesI. Ya. Postovsky Institute of Organic SynthesisEkaterinburgRussian Federation
  2. 2.Ural State Agrarian UniversityEkaterinburgRussian Federation
  3. 3.Ural Federal University named after the first President of Russia B. N. YeltsinInstitute of Chemical EngineeringEkaterinburgRussian Federation
  4. 4.Ural Research Institute for Dermatology, Venereology, and ImmunopathologyEkaterinburgRussian Federation
  5. 5.Ministry of Health of the Russian FederationUral State Medical UniversityEkaterinburgRussian Federation

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