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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1116–1121 | Cite as

Synthesis of succinic monoamide avermectin esters

  • M. A. Shchetinina
  • E. I. Chernoburova
  • N. G. Kolotyrkina
  • M. Kh. Dzhafarov
  • F. I. Vasilevich
  • I. V. ZavarzinEmail author
Full Article
  • 4 Downloads

Abstract

Reaction of avermectin B1 hemisuccinate with N-hydroxysuccinimide and N,N’-dicyclohexylcarbodiimide followed by amination provided succinic monoamide avermectine esters that are potential antiparasitics.

Key words

avermectin B1 hemisuccinates N-hydroxysuccinimide N,N’-dicyclohexylcarbodiimide amines succinic anhydride amides antiparasitic activity 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • M. A. Shchetinina
    • 1
  • E. I. Chernoburova
    • 1
  • N. G. Kolotyrkina
    • 1
  • M. Kh. Dzhafarov
    • 2
  • F. I. Vasilevich
    • 2
  • I. V. Zavarzin
    • 1
    Email author
  1. 1.N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of SciencesMoscowRussian Federation
  2. 2.K. I. Skryabin Moscow State Academy of Veterinary Medicine and BiotechnologyMoscowRussian Federation

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