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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1109–1115 | Cite as

Synthesis of 4″O,5O-bis(2-amino-2-thioxoacetyl)ivermectin derivatives

  • M. A. Shchetinina
  • E. I. Chernoburova
  • N. G. Kolotyrkina
  • G. I. Kovalev
  • I. I. Tsepilova
  • K. S. Krivonos
  • A. V. Kolobov
  • M. Kh. Dzhafarov
  • T. A. Tikhonova
  • Yu. A. Volkova
  • F. I. Vasilevich
  • I. V. ZavarzinEmail author
Full Article
  • 4 Downloads

Abstract

Reaction of 4″O,5O-bis(chloroacetyl)ivermectin with amines in the presence of sulfur provided the corresponding bis(2-amino-2-thioxoacetyl) derivatives that are potential antiparasitics.

Key words

avermectin B1 ivermectin thioamides amines 4″O,5O-bis(2-amino-2-thioxo)-ivermectin the Willgerodt—Kindler reaction antiparasitic activity 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • M. A. Shchetinina
    • 1
  • E. I. Chernoburova
    • 1
  • N. G. Kolotyrkina
    • 1
  • G. I. Kovalev
    • 2
  • I. I. Tsepilova
    • 3
  • K. S. Krivonos
    • 3
  • A. V. Kolobov
    • 4
  • M. Kh. Dzhafarov
    • 3
  • T. A. Tikhonova
    • 1
  • Yu. A. Volkova
    • 1
  • F. I. Vasilevich
    • 3
  • I. V. Zavarzin
    • 1
    Email author
  1. 1.N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of SciencesMoscowRussia
  2. 2.Scientific-Research Institute of Pharmacology named after V. V. ZakusovMoscowRussia
  3. 3.K. I. Skryabin Moscow State Academy of Veterinary Medicine and BiotechnologyMoscowRussia
  4. 4.Yaroslavl State Technical UniversityYaroslavlRussia

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