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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1096–1101 | Cite as

Phosphocreatine immobilization of the surface of silica and magnetite nanoparticles for targeted drug delivery

  • D. V. KorolevEmail author
  • N. V. Evreinova
  • E. V. Zakharova
  • K. G. Gareev
  • E. B. Naumysheva
  • D. V. Postnov
  • V. N. Postnov
  • M. M. Galagudza
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Abstract

A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreatine than silica nanoparticles. The method was recommended for practical application.

Key words

magnetite nanoparticles silica nanoparticles amination phosphocreatine immobilization 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • D. V. Korolev
    • 1
    • 2
    Email author
  • N. V. Evreinova
    • 1
    • 3
  • E. V. Zakharova
    • 4
  • K. G. Gareev
    • 4
  • E. B. Naumysheva
    • 1
    • 5
  • D. V. Postnov
    • 5
  • V. N. Postnov
    • 1
    • 5
  • M. M. Galagudza
    • 1
    • 2
  1. 1.Almazov National Medical Research CentreSt. PetersburgRussian Federation
  2. 2.First Pavlov State Medical University of St. PetersburgSt. PetersburgRussian Federation
  3. 3.St. Petersburg State Technological Institute (Technical University)St. PetersburgRussian Federation
  4. 4.St. Petersburg Electrotechnical University “LETI”St. PetersburgRussian Federation
  5. 5.St. Petersburg State UniversitySt. PetersburgRussian Federation

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