Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones
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A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.
Key wordsmonoterpenoids montmorillonite K10 heterocyclic compounds analgesic activity
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