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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1061–1066 | Cite as

Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones

  • I. V. Il’ina
  • D. V. Korchagina
  • E. A. Morozova
  • T. G. Tolstikova
  • K. P. VolchoEmail author
  • N. F. Salakhutdinov
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Abstract

A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.

Key words

monoterpenoids montmorillonite K10 heterocyclic compounds analgesic activity 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • I. V. Il’ina
    • 1
    • 2
  • D. V. Korchagina
    • 1
  • E. A. Morozova
    • 1
  • T. G. Tolstikova
    • 1
  • K. P. Volcho
    • 1
    • 2
    Email author
  • N. F. Salakhutdinov
    • 1
    • 2
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussian Federation
  2. 2.Novosibirsk National Research State UniversityNovosibirskRussian Federation

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