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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1041–1046 | Cite as

Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections

  • A. S. SokolovaEmail author
  • D. V. Baranova
  • O. I. Yarovaya
  • D. S. Baev
  • O. A. Polezhaeva
  • A. V. Zybkina
  • D. N. Shcherbakov
  • T. G. Tolstikova
  • N. F. Salakhutdinov
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Abstract

N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

Key words

Marburg virus Ebola virus pseudotyped viruses (1S)-(+)-camphor-10-sulfonic acid N-heterocycles molecular docking 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • A. S. Sokolova
    • 1
    Email author
  • D. V. Baranova
    • 1
    • 2
  • O. I. Yarovaya
    • 1
    • 2
  • D. S. Baev
    • 1
    • 2
  • O. A. Polezhaeva
    • 3
  • A. V. Zybkina
    • 3
  • D. N. Shcherbakov
    • 3
  • T. G. Tolstikova
    • 1
    • 2
  • N. F. Salakhutdinov
    • 1
    • 2
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussian Federation
  2. 2.Novosibirsk State UniversityNovosibirskRussian Federation
  3. 3.State Research Center of Virology and Biotechnology “Vector”Koltsovo, Novosibirsk RegionRussian Federation

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