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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1036–1040 | Cite as

A new original approach to the design of anticancer drugs based on energy-rich quadricyclanes

  • U. M. Dzhemilev
  • A. R. Akhmetov
  • A. A. Khuzin
  • V. A. D’yakonov
  • L. U. Dzhemileva
  • M. M. Yunusbaeva
  • L. M. Khalilov
  • A. R. TuktarovEmail author
Full Article
  • 8 Downloads

Abstract

Quadricyclane derivatives are shown for the first time to be promising for application as anticancer drugs. The efficiency of such cage compounds is mainly due to thermal action on cancer cells resulting from a C—C bond cleavage in quadricyclane on exposure to catalytic amounts of cisplatin Pt ions.

Key words

norbornadiene quadricyclane anticancer activity 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • U. M. Dzhemilev
    • 1
  • A. R. Akhmetov
    • 1
  • A. A. Khuzin
    • 1
  • V. A. D’yakonov
    • 1
  • L. U. Dzhemileva
    • 1
  • M. M. Yunusbaeva
    • 1
  • L. M. Khalilov
    • 1
  • A. R. Tuktarov
    • 1
    Email author
  1. 1.Institute of Petroleum Chemistry and CatalysisRussian Academy of SciencesUfa, Republic of BashkortostanRussian Federation

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