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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1031–1035 | Cite as

New aspects of using biologically active thioterpenoids of pinane series

  • L. E. NikitinaEmail author
  • S. V. Kiselev
  • V. A. Startseva
  • O. A. Lodochnikova
  • A. A. Rakhmatullina
  • I. V. Fedyunina
  • I. R. Gilfanov
Full Article

Abstract

Pinane sulfi de obtained by the addition of methyl hydrosulfanylacetate at the double bond of β-pinene inhibits platelet receptor activity. It inhibits completely platelet aggregation induced by adrenaline, ADP, collagen, arachidonic acid, and also reduces the eff ect of ristomycin. This compound inhibits both platelet and coagulation hemostasis, which allows one to use it for creation promising antiaggregation drugs and for stabilization blood products.

Key words

organosulfur compounds sulfi des monoterpenoids pinane derivatives platelets antiaggregation and anticoagulant activity 

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References

  1. 1.
    K. Candela, R. Fellous, D. Joulain, R. Faure, Flavour. Frag. J., 2003, 18, 52.CrossRefGoogle Scholar
  2. 2.
    L. E. Nikitina, N. P. Artemova, V. A. Startseva, I. V. Fedyunina, V. V. Klochkov, Chem. Nat. Compd., 2017, 5, 811.CrossRefGoogle Scholar
  3. 3.
    G. Yu. Ishmuratov, M. P. Yakovleva, A. G. Tolstikov, V. S. Tukhvatshin, R. F. Talipov, L. E. Nikitina, N. P. Artemova, V. A. Startseva, Chem. Nat. Compd., 2014, 50, 22.CrossRefGoogle Scholar
  4. 4.
    L. E. Nikitina, V. A. Startseva, I. A. Vakulenko, V. V. Plemenkov, Russ. J. Gen. Chem. (Engl. Transl.), 2002, 72, 974.CrossRefGoogle Scholar
  5. 5.
    I. V. Il/ina, К. P. Volcho, N. F. Salakhutdinov, Russ. J. Org. Chem. (Engl. Transl.), 2008, 44, 1.CrossRefGoogle Scholar
  6. 6.
    L. E. Nikitina, N. P. Artemova, V. A. Startseva, Prirodnie i tiomodifizirovannie monoterpenoidi [Natural and Thio-Modifi ed Monoterpenoids], Otechestvo, Kazan, 2011, 156 pp.Google Scholar
  7. 7.
    L. E. Nikitina, V. A. Startseva, S. A. Dieva, I. A. Vakulenko, G. A. Shamov, Chem. Nat. Compd., 2006, 2, 178.CrossRefGoogle Scholar
  8. 8.
    I. A. Vakulenko, V. A. Startseva, L. E. Nikitina, N. P. Artemova, L. L. Frolova, A. V. Kuchin, Chem. Nat. Compd., 2005, 41, 686.CrossRefGoogle Scholar
  9. 9.
    V. A. Startseva, L. E. Nikitina, O. A. Lodochnikova, A. E. Klimovitskii, A. V. Arefjev, N. P. Artemova, A. V. Bodrov, R. Z. Musin, E. N. Klimovitskii, Phosphorus, Sulfur, Silicon Relat. Elem., 2013, 189, 615.CrossRefGoogle Scholar
  10. 10.
    O. A. Lodochnikova, D. B. Krivolapov, V. A. Startseva, L. E. Nikitina, A. V. Bodrov, N. P. Artemova, V. V. Klochkov, T. I. Madzhidov, I. A. Litvinov, Phosphorus, Sulfur, Silicon Relat. Elem., 2015, 190, 2222.CrossRefGoogle Scholar
  11. 11.
    L. E. Nikitina, O. A. Lodochnikova, V. A. Startseva, A. V. Bodrov, N. P. Artemova, A. E. Klimovitskii, V. V. Klochkov, Phosphorus, Sulfur, Silicon Relat. Elem., 2017, 192, 187.CrossRefGoogle Scholar
  12. 12.
    O. A. Lodochnikova, V. A. Startseva, L. E. Nikitina, A. V. Bodrov, A. E. Klimovitskii, E. N. Klimovitskii, I. A. Litvinov, CrystEngComm, 2014, 16, 4314.CrossRefGoogle Scholar
  13. 13.
    K. M. Steed, J. W. Steed, Chem. Rev., 2015, 115, 2895.CrossRefGoogle Scholar
  14. 14.
    L. E. Nikitina, V. A. Startseva, I. A. Vakulenko, I. M. Khismatulina, S. A. Lisovskaya, N. P. Glushko, R. S. Fassakhov, Pharm. Chem. J., 2009, 43, 251.CrossRefGoogle Scholar
  15. 15.
    V. V. Gavrilov, V. A. Startseva, L. E. Nikitina, O. A. Lodochnikova, O. I. Gnezdilov, S. A. Lisovskaya, N. I. Glushko, E. N. Klimovitskii, Pharm. Chem. J. (Engl. Transl.), 2010, 44, 126.CrossRefGoogle Scholar
  16. 16.
    S. V. Pestova, D. V. Sudarikov, S. A. Rubtsova, A. V. Kuchin, Russ. J. Org. Chem., 2013, 49, 366.CrossRefGoogle Scholar
  17. 17.
    S. V. Pestova, E. S. Izmest’ev, O. G. Shevchenko, S. A. Rubtsova, A. V. Kuchin, Russ. Chem. Bull., 2015, 64, 723.CrossRefGoogle Scholar
  18. 18.
    S. V. Pestova, E. S. Izmest'ev, O. G. Shevchenko, S. A. Rubtsova, A. V. Кuchin, Bull. RFBR, 2016, 1, 13 (in Russian).Google Scholar
  19. 19.
    Yu. V. Gyrdymova, M. Ya. Demakova, O. G. Shevchenko, D. V. Sudarikov, L. L. Frolova, S. A. Rubtsova, A. V. Kuchin, Chem. Nat. Compd., 2017, 53, 895.CrossRefGoogle Scholar
  20. 20.
    O. G. Shevchenko, S. N. Plyusnina, E. V. Buravlev, I. Yu. Chukicheva, I. V. Fedorova, O. V. Shchukina, A. V. Kuchin, Russ. Chem. Bull., 2017, 66, 1881.CrossRefGoogle Scholar
  21. 21.
    M. V. Mal’shakova, L. L. Frolova, I. N. Alekseev, A. V. Kuchin, S. A. Patov, D. V. Belykh, Russ. Chem. Bull., 2018, 67, 1467.CrossRefGoogle Scholar
  22. 22.
    S. V. Kiselev, L. E. Nikitina, V. A. Startseva, N. P. Artemova, A. V. Bodrov, S. V. Boichuk, M. M. Vorontsova, A. A. Rakhmatullina, R. G. Turaev, V. V. Klochkov, Pharm. Chem. J. (Engl. Transl.), 2017, 51, 343.CrossRefGoogle Scholar
  23. 23.
    L. E. Nikitina, S. V. Kiselev, V. A. Startseva, A. V. Bodrov, Z. R. Azizova, O. T. Shipina, I. V. Fedyunina, S. V. Boichuk, O. A. Lodochnikova, V. V. Klochkov, L. F. Galiullina, A. V. Khaliullina, Front. Pharmacol., 2018, 9, 116.CrossRefGoogle Scholar
  24. 24.
    Ya. M. Varshavskii, Ustanovlenie strukturi organicheskikh soedinenii fi zicheskimi i khimicheskimi metodami [Establishment of the Structure of Organic Compounds by Physical and Chemical Methods], Khimiya, Moscow, 1967, 800 pp. (in Russian).Google Scholar
  25. 25.
    L. V. Iversen, O. Ostergaard, C. T. Nielsen, Ch. Lood, A. Voss, A. B. Soren, J. Niels, H. H. Heegaard, J. Immunol. Methods, 2013, 388, 49.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • L. E. Nikitina
    • 1
    Email author
  • S. V. Kiselev
    • 1
  • V. A. Startseva
    • 1
  • O. A. Lodochnikova
    • 2
  • A. A. Rakhmatullina
    • 3
  • I. V. Fedyunina
    • 1
  • I. R. Gilfanov
    • 1
  1. 1.Kazan State Medical UniversityKazanRussian Federation
  2. 2.A. E. Arbuzov Institute of Organic and Physical ChemistryFederal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”KazanRussian Federation
  3. 3.Republican Blood CenterKazanRussian Federation

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