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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1025–1030 | Cite as

Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors

  • V. A. Mumyatova
  • G. I. Kozub
  • T. A. Kondrat’eva
  • A. A. Terent’ev
  • N. A. SaninaEmail author
Full Article
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Abstract

The biological activity of a series of sulfur-nitrosyl iron complexes (NICs) depends on the structure of the ligands and the position of the functional groups in the aromatic ring of the ligand. Differences in susceptibility of the gram-positive and gram-negative bacteria to the NICs was found. The series of the studied NICs suppresses the formation of biofilms of Micrococcus luteus bacteria. The obtained results demonstrate that the studied complexes can serve as the basis for the preparation of antibacterial agents.

Key words

nitric oxide binuclear tetranitrosyl iron complexes mononuclear dinitrosyl iron complexes antibacterial activity 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • V. A. Mumyatova
    • 1
    • 2
  • G. I. Kozub
    • 1
    • 2
  • T. A. Kondrat’eva
    • 1
    • 2
  • A. A. Terent’ev
    • 1
    • 2
    • 3
  • N. A. Sanina
    • 1
    • 2
    • 3
    Email author
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation
  2. 2.Medicinal Chemistry Research and Education CenterMoscow Region State UniversityMytishchi, Moscow RegionRussian Federation
  3. 3.Department of Fundamental Physical and Chemical EngineeringM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

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