Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1025–1030 | Cite as

Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors

  • V. A. Mumyatova
  • G. I. Kozub
  • T. A. Kondrat’eva
  • A. A. Terent’ev
  • N. A. SaninaEmail author
Full Article


The biological activity of a series of sulfur-nitrosyl iron complexes (NICs) depends on the structure of the ligands and the position of the functional groups in the aromatic ring of the ligand. Differences in susceptibility of the gram-positive and gram-negative bacteria to the NICs was found. The series of the studied NICs suppresses the formation of biofilms of Micrococcus luteus bacteria. The obtained results demonstrate that the studied complexes can serve as the basis for the preparation of antibacterial agents.

Key words

nitric oxide binuclear tetranitrosyl iron complexes mononuclear dinitrosyl iron complexes antibacterial activity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. J. Kutner, A. J. Friedman, Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol., 2013, 5, 502.Google Scholar
  2. 2.
    J. Park, J. Kima, K. Singha, D.-K. Han, H. Park, W. J. Kima, Biomaterials, 2013, 34, 8766.CrossRefGoogle Scholar
  3. 3.
    J. Pant, J. Gao, M. J. Goudie, S. P. Hopkins, J. Locklin, H. Handa, Acta Biomater., 2017, 58, 421.CrossRefGoogle Scholar
  4. 4.
    S. Priya, R. Nithya, S. Berchmans, J. Mater. Sci.: Mater. Med., 2014, 25, 1.Google Scholar
  5. 5.
    A. B. Seabra, G. Z. Justo, P. S. Haddad, Biotechnol. Adv., 2015, 33, 1370.CrossRefGoogle Scholar
  6. 6.
    H. Nurhasni, J. Cao, M. Choi, I. Kim, B. L. Lee, Y. Jung, J.-W. Yoo, Int. J. Nanomed., 2015, 10, 3065.Google Scholar
  7. 7.
    N. A. Reger, W. S. Meng, E. S. Gawalt, J. Funct. Biomater., 2017, 8, 20.CrossRefGoogle Scholar
  8. 8.
    B. J. Privett, A. D. Broadnax, S. J. Bauman, D. A. Riccio, M. H. Schoenfisch, Nitric Oxide, 2012, 26, 169.CrossRefGoogle Scholar
  9. 9.
    P. G. Wang, M. Xian, X. Tang, X. Wu, Z. Wen, T. Cai, A. J. Janczuk, Chem. Rev., 2002, 102, 1091.CrossRefGoogle Scholar
  10. 10.
    S. V. Kurmaz, T. N. Rudneva, N. A. Sanina, Mendeleev Commun., 2018, 28, 73.CrossRefGoogle Scholar
  11. 11.
    A. V. Nyuchev, E. N. Kochetkov, K. V. Schegravin, O. G. Zamyshlyayeva, M. A. Baten´kin, M. A. Samsonov, O. I. Koifman, Y. V. Romanenko, N. B. Melnikova, A. Yu. Fedorov, Mendeleev Commun., 2017, 27, 610.CrossRefGoogle Scholar
  12. 12.
    N. A. Sanina, G. I. Kozub, T. A. Kondrat'eva, S. M. Aldoshin, Pat. RF 2494104, Byul. Izobr. [Invention Bulletin], 2013, No. 27 (in Russian).Google Scholar
  13. 13.
    N. A. Sanina, N. S. Emel´yanova, A. N. Chekhlov, A. F. Shestakov, I. V. Soulimenkov, S. M. Aldoshin, Russ. Chem. Bull., 2010, 59, 1104.Google Scholar
  14. 14.
    G. I. Kozub, N. A. Sanina, N. S. Emel´yanova, A. N. Utenishev, T. A. Kondrat´eva, V. N. Khrustalev, N. S. Ovanesyan, N. E. Kupchinskaya, S. M. Aldoshin, Inorg. Chim. Acta, 2018, 480, 132.CrossRefGoogle Scholar
  15. 15.
    N. A. Sanina, G. I. Kozub, O. C. Zhukova, N. S. Emel´yanova, T. A. Kondrat´eva, D. V. Korchagin, G. V. Shilov, N. S. Ovanesyan, S. M. Aldoshin, J. Coord. Chem., 2013, 66, 3602.CrossRefGoogle Scholar
  16. 16.
    N. A. Senina, G. I. Kozub, T. A. Kondrat´eva, A. A. Terent´ev, V. A. Mumyatova, P. Yu. Barzilovich, N. S. Ovanesyan, S. M. Aldoshin, Russ. Chem. Bull., 2017, 66, 1706.CrossRefGoogle Scholar
  17. 17.
    N. A. Sanina, G. V. Shilov, S. M. Aldoshin, A. F. Shestakov, L. A. Syrtsova, N. S. Ovanesyan, E. S. Chudinova, N. I. Shkondina, N. S. Emel´yanova, A. I. Kotel´nikov, Russ. Chem. Bull., 2009, 58, 560.Google Scholar
  18. 18.
    O. A. Rakova, N. A. Sanina, G. V. Shilov, Yu. M. Shulga, V. M. Martynenko, N. S. Ovanesyan, S. M. Aldoshin, Russ. J. Coord. Chem., 2002, 28, 341.CrossRefGoogle Scholar
  19. 19.
    N. A. Sanina, S. M. Aldoshin, N. Yu. Shmatko, D. V. Kor-chagin, G. V. Shilov, N. S. Knyaz´kina, N. S. Ovanesyan, A. V. Kulikov, New J. Chem., 2015, 39, 1022.CrossRefGoogle Scholar
  20. 20.
    N. Yu. Shmatko, D. V. Korchagin, G. V. Shilov, N. S. Ovanesyan, A. V. Kulikov, N. A. Sanina, S. M. Aldoshin, Polyhedron, 2017, 137, 72.CrossRefGoogle Scholar
  21. 21.
    N. A. Sanina, S. M. Aldoshin, N. Yu. Shmatko, D. V. Korchagin, G. V. Shilov, N. S. Ovanesyan, A. V. Kulikov, Inorg. Chem. Commun., 2014, 49, 44.CrossRefGoogle Scholar
  22. 22.
    N. A. Sanina, N. Yu. Shmatko, D. V. Korchagin, G. V. Shilov, A. A. Terent´ev, T. S. Stupina, A. A. Balakina, N. V. Komleva, N. S. Ovanesyan, A. V. Kulikov, S. M. Aldoshin, J. Coord. Chem., 2016, 69, 812.CrossRefGoogle Scholar
  23. 23.
    T. C. Chou, P. Talalay, Adv. Enzyme Regul., 1984, 22, 27.CrossRefGoogle Scholar
  24. 24.
    A. J. F. Egan, Mol. Microbiol., 2018, 107, 676.CrossRefGoogle Scholar
  25. 25.
    A. M. Glauert, M. J. Thornley, Annu. Rev. Microbiol., 1969, 23, 159.CrossRefGoogle Scholar
  26. 26.
    E. A. Machtiger, C. F. Fox, Annu. Rev. Biochem., 1973, 42, 575.CrossRefGoogle Scholar
  27. 27.
    Y. Bi, X. Yang, T. Zhang, Z. Liu, X. Zhang, J. Lu, K. Cheng, J. Xu, H. Wang, G. Lv, P. J. Lewis, Q. Meng, C. Ma, Eur. J. Med. Chem., 2015, 101, 71.CrossRefGoogle Scholar
  28. 28.
    R. N. Allan, S. Morgan, S. Brito-Mutunayagam, P. Skipp, M. Feelisch, S. M. Hayes, W. Hellier, S. C. Clarke, P. Stoodley, A. Burgess, H. Ismail-Koch, R. J. Salib, J. S. Webb, S. N. Faust, L. Hall-Stoodleya, Antimicrob. Agents Chemother., 2016, 60, 2456.CrossRefGoogle Scholar
  29. 29.
    G. F. dos Santos Fernandes, P. C. de Souza, L. B. Marino, K. Chegaev, S. Guglielmo, L. Lazzarato, R. Fruttero, M. C. Chung, F. R. Pavan, J. L. dos Santos, Eur. J. Med. Chem., 2016, 123, 523.CrossRefGoogle Scholar
  30. 30.
    J. Jones-Carson, J. R. Laughlin, A. L. Stewart, M. I. Voskuil, A. Vázquez-Torres, Nitric Oxide, 2012, 27, 25.CrossRefGoogle Scholar
  31. 31.
    C. Chan, T. C. Hardin, J. I. Smart, Future Microbiol., 2015, 10, 1325.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • V. A. Mumyatova
    • 1
    • 2
  • G. I. Kozub
    • 1
    • 2
  • T. A. Kondrat’eva
    • 1
    • 2
  • A. A. Terent’ev
    • 1
    • 2
    • 3
  • N. A. Sanina
    • 1
    • 2
    • 3
    Email author
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation
  2. 2.Medicinal Chemistry Research and Education CenterMoscow Region State UniversityMytishchi, Moscow RegionRussian Federation
  3. 3.Department of Fundamental Physical and Chemical EngineeringM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

Personalised recommendations