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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 1000–1005 | Cite as

Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments

  • I. A. DvornikovaEmail author
  • E. V. Buravlev
  • I. V. Fedorova
  • O. G. Shevchenko
  • I. Yu. Chukicheva
  • A. V. Kutchin
Full Article

Abstract

A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.

Key words

1H-benzimidazoles sterically hindered phenols isobornylphenols antioxidant activity membrane-protective activity red blood cells oxidative hemolysis 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • I. A. Dvornikova
    • 1
    Email author
  • E. V. Buravlev
    • 1
  • I. V. Fedorova
    • 1
  • O. G. Shevchenko
    • 2
  • I. Yu. Chukicheva
    • 1
  • A. V. Kutchin
    • 1
  1. 1.Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of SciencesSyktyvkarRussian Federation
  2. 2.Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of SciencesSyktyvkarRussian Federation

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