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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 993–999 | Cite as

Composition and properties of the reaction products of p-cresol with camphene

  • I. Yu. ChukichevaEmail author
  • E. V. Buravlev
  • I. A. Dvornikova
  • I. V. Fedorova
  • G. A. Chernysheva
  • O. I. Aliev
  • V. I. Smol’yakova
  • A. M. Anishchenko
  • A. V. Sidekhmenova
  • M. B. Plotnikov
  • A. V. Kutchin
Full Article

Abstract

The products of the reaction between p-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological activity of the most active stereoisomer of 2,6-diisobornyl-4-methyl phenol in rats with a model of streptozotocin diabetes was studied. Under these conditions, the investigated compound during course administration improves micro- and macrorheological parameters of blood, exhibits a membranestabilizing eff ect on erythrocytes, restricts platelet aggregation, and favors the preservation of the vasodilator function of endothelium.

Key words

2,6-diisobornyl-4-methylphenol hemorheological activity erythrocyte aggregation erythrocyte deformability platelet aggregation erythrocyte osmotic resistance endothelial dysfunction 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • I. Yu. Chukicheva
    • 1
    Email author
  • E. V. Buravlev
    • 1
  • I. A. Dvornikova
    • 1
  • I. V. Fedorova
    • 1
  • G. A. Chernysheva
    • 2
  • O. I. Aliev
    • 2
  • V. I. Smol’yakova
    • 2
  • A. M. Anishchenko
    • 2
  • A. V. Sidekhmenova
    • 2
  • M. B. Plotnikov
    • 2
  • A. V. Kutchin
    • 1
  1. 1.Institute of Chemistry, Komi Scientific CenterUral Branch of the Russian Academy of SciencesSyktyvkarRussia
  2. 2.Goldberg Research Institute of Pharmacology and Regenerative MedicineTomsk National Research Medical Center of the Russian Academy of SciencesTomskRussia

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