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Russian Chemical Bulletin

, Volume 68, Issue 5, pp 946–954 | Cite as

Pro- and antioxidant properties of uracil derivatives

  • Yu. I. MurinovEmail author
  • S. A. Grabovskii
  • N. N. Kabal’nova
Review
  • 9 Downloads

Abstract

The review summarizes data on pro- and antioxidant properties of uracil derivatives comprising an important group of pharmacologically active compounds. The presence of OH or NH2 groups at position 5 of the uracil ring was shown to be essential for these compounds to have both antioxidant and prooxidant properties. The mechanism of pro- and antioxidant action is discussed.

Key words

uracil derivatives antioxidants prooxidants variable-valence metal ions fixation and activation of molecular oxygen reactive oxygen species 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • Yu. I. Murinov
    • 1
    Email author
  • S. A. Grabovskii
    • 1
  • N. N. Kabal’nova
    • 1
  1. 1.Ufa Institute of Chemistry, Ufa Federal Research CentreRussian Academy of SciencesUfaRussian Federation

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